Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study
Overgaard SH, Sørensen SB, Munk HL, Nexøe AB, Glerup H, Henriksen RH, Guldmann T, Pedersen N, Saboori S, Hvid L, Dahlerup JF, Hvas CL, Jawhara M, Andersen KW, Pedersen AK, Nielsen OH, Bergenheim F, Brodersen JB, Heitmann BL, Halldorsson TI, Holmskov U, Bygum A, Christensen R, Kjeldsen J, Ellingsen T, Andersen V
Frontiers in nutrition · 17 citas
Etiquetas de revisión
Vínculos de autores con la industriaCuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Oak Foundation
- Organización sin fines de lucro
- Parker Institute for Cancer Immunotherapy
- Gobierno
- European Commission
- Universidad u hospital
- Odense Universitetshospital
- Organización sin fines de lucro
- Knud og Edith Eriksens Mindefond
- Gobierno
- Horizon 2020
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Parker Institute for Cancer Immunotherapy (OCAY-18-774-OFIL); European Commission (HORIZON2020); European Commission (733100)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-10-13 · Front Nutr · vol. 9 · pág. 985732
- Editorial
- Frontiers Media
- Citado
- 17 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Inflammatory Bowel Disease · Gut microbiota and health · Rheumatoid Arthritis Research and Therapies
- Palabras clave
- Medicine, Prospective cohort study, Cohort, Cohort study, Internal medicine, Intensive care medicine
26 autores
- Silja Hvid Overgaard🇩🇰 · autor de correspondenciaUniversity of Southern Denmark; Frederiksberg Hospital
- Signe Bek Sørensen🇩🇰University of Southern Denmark
- Heidi Lausten Munk🇩🇰University of Southern Denmark; Odense University Hospital
- Anders Bathum Nexøe🇩🇰University of Southern Denmark; Odense University Hospital
- Henning Glerup🇩🇰Regionshospitalet Silkeborg
- Rikke Holm Henriksen🇩🇰Regionshospitalet Silkeborg
- Tanja Guldmann🇩🇰Regionshospitalet Silkeborg
- Natalia Pedersen🇩🇰Slagelse Hospital
- Sanaz Saboori🇩🇰Slagelse Hospital
- Lone Hvid🇩🇰Odense University Hospital
- Jens Frederik Dahlerup🇩🇰Aarhus University Hospital
- Christian Lodberg Hvas🇩🇰Aarhus University Hospital
- Mohamad Jawhara🇩🇰University of Southern Denmark
- Karina Winther Andersen🇩🇰University of Southern Denmark
- Andreas Kristian Pedersen
- Ole Haagen Nielsen🇩🇰University of Copenhagen; Herlev Hospital
- Fredrik Holmberg Bergenheim🇩🇰University of Copenhagen; Herlev Hospital
- Jacob Broder Brodersen🇩🇰University of Southern Denmark; Hospital South West Jutland
- Berit L. Heitmann🇩🇰University of Copenhagen; Frederiksberg Hospital
- Thorhallur Ingi Halldorsson🇮🇸University of Iceland
- Uffe Holmskov🇩🇰University of Southern Denmark
- Anette Bygum🇩🇰University of Southern Denmark; Odense University Hospital
- Robin Christensen🇩🇰University of Southern Denmark; Frederiksberg Hospital; Odense University Hospital
- Jens Kjeldsen🇩🇰University of Southern Denmark; Odense University Hospital
- Torkell Ellingsen🇩🇰University of Southern Denmark; Odense University Hospital
- Vibeke Charlotte Andersen🇩🇰University of Southern Denmark
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Biologic disease-modifying drugs have revolutionised the treatment of a number of chronic inflammatory diseases (CID). However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for optimization of treatment strategies.
Objective
To investigate if the treatment outcome of biological therapy is associated with the habitual dietary intake of fibre and red/processed meat in patients with a CID.
Methods
In this multicentre prospective cohort study, we consecutively enrolled 233 adult patients with a diagnosis of Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis (RA), Axial Spondyloarthritis, Psoriatic Arthritis and Psoriasis, for whom biologic therapy was planned, over a 3 year period. Patients with completed baseline food frequency questionnaires were stratified into a high fibre/low red and processed meat exposed group (HFLM) and an unexposed group (low fibre/high red and processed meat intake = LFHM). The primary outcome was the proportion of patients with a clinical response to biologic therapy after 14-16 weeks of treatment.
Results
Of the 193 patients included in our primary analysis, 114 (59%) had a clinical response to biologic therapy. In the HFLM group (N = 64), 41 (64%) patients responded to treatment compared to 73 (56%) in the LFHM group (N = 129), but the difference was not statistically significant (OR: 1.48, 0.72-3.05). For RA patients however, HFLM diet was associated with a more likely clinical response (82% vs. 35%; OR: 9.84, 1.35-71.56).
Conclusion
Habitual HFLM intake did not affect the clinical response to biological treatment across CIDs. HFLM diet in RA patients might be associated with better odds for responding to biological treatment, but this would need confirmation in a randomised trial.
Trial registration
(clinicaltrials.gov), identifier [NCT03173144].
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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