The basis and design for time-restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE-CRC trial)
Gabel K, Fitzgibbon ML, Yazici C, Gann P, Sverdlov M, Guzman G, Chen Z, McLeod A, Hamm A, Varady KA, Tussing-Humphreys L
Obesity (Silver Spring, Md.) · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NCI NIH HHS
- Gobierno
- NIMHD NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (R01CA257807); National Institute on Minority Health and Health Disparities (U54MD012523); National Cancer Institute (T32CA057699); National Cancer Institute (R01CA204808); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119783); National Institutes of Health (R01CA257807); National Institutes of Health (T32 CA057699); National Institutes of Health (R01 DK119783); National Cancer Institute (R01CA250390)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-11-01 · Obesity (Silver Spring) · vol. 30 · número 12 · págs. 2376–2385
- Editorial
- Wiley
- Citado
- 9 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Enhanced Recovery After Surgery
- Palabras clave
- time-restricted eating, colorectal cancer prevention, weight loss, dietary adherence, oxidative stress, inflammation, insulin resistance, body composition
- MeSH
- animals, humans, colorectal neoplasms, obesity, weight loss, caloric restriction, fasting, risk reduction behavior, adult, tumor microenvironment
11 autores
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Marian Fitzgibbon🇺🇸University of Illinois Chicago
- Cemal Yazıcı🇺🇸University of Illinois Chicago
- Peter H. Gann🇺🇸University of Illinois Chicago
- Maria S. Sverdlov🇺🇸University of Illinois Chicago
- Grace Guzman🇺🇸University of Illinois Chicago
- Zhengjia Chen🇺🇸University of Illinois Chicago
- Andrew McLeod🇺🇸University of Illinois Chicago
- Alyshia Hamm🇺🇸University of Illinois Chicago
- Krista A Varady🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
- Lisa Marie Tussing-Humphreys🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Approximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal-R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time-restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects.
Methods
The authors describe a 12-month randomized controlled trial of 8-hour TRE (ad libitum 12 PM-8 PM), Cal-R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity.
Results
Effects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight/composition and CRC risk markers.
Conclusions
This study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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