The Effect of Walnut Intake on Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Alshahrani SM, Mashat RM, Almutairi D, Mathkour A, Alqahtani SS, Alasmari A, Alzahrani AH, Ayed R, Asiri MY, Elsherif A, Alsabaani A
Nutrients · 16 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-10-23 · Nutrients · vol. 14 · número 21 · pág. 4460
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 24 citas · más que el 71% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 74 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- Juglans regia, dietary intervention, serum lipids, dyslipidemia, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, cardiovascular risk, overweight and obesity, comorbidities, trial duration
- MeSH
- humans, juglans, cardiovascular diseases, cholesterol, lipids, triglycerides, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic
11 autores
- Saeed Mastour Alshahrani🇸🇦 · autor de correspondenciaKing Khalid University
- Reham M. Mashat🇸🇦King Khalid University
- Diaa AlmutairiPrince Sultan Military College of Health Sciences
- Alaa A. Mathkour🇸🇦Ministry of Health
- Sahar Saad Alqahtani🇸🇦King Khalid University
- Amirah Alasmari🇸🇦Ministry of Health
- Abdullah Hassan Alzahrani🇸🇦Ministry of Health
- Reem Ayed
- Mohammed Yahya Asiri🇸🇦Ministry of Health
- Alsanussi Elsherif🇱🇾University of Benghazi
- Abdullah Abdulmohsen Alsabaani🇸🇦King Khalid University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cardiovascular diseases (CVD) are the leading causes of death worldwide. Dyslipidemia is a cardiometabolic risk factor of CVD, yet it can be modifiable. Walnuts have been suggested as a dietary intervention to improve the lipid profile. Therefore, we reviewed the literature to assess the evidence linking walnut intake to the improvement of blood lipids, including total cholesterol (TC), low-density lipoprotein (LDL-C) cholesterol, high-density lipoprotein (HDL-C) cholesterol, and triglycerides (TG). PubMed and Embase databases were searched from 2010 up to March 2022. We limited our search to randomized controlled trials conducted on humans and published in English during the specified period. Cochrane's risk of bias tool for interventional studies was used. A random-effects model was used for the meta-analysis, and weighted mean differences were obtained (WMD) Thirteen trials from the U.S., Europe, and Asia were included. Walnut intake was associated with significant reductions in TC (WMD: -8.58 mg/dL), LDL-C (WMD: -5.68 mg/dL), and TG (WMD: -10.94 mg/dL). Walnut consumption was not associated with HDL-C. Subgroup analysis showed that overweight/obese and those with comorbidities had more lipid improvement. A longer trial duration did result in further improvements. However, our results may be prone to bias due to extraneous confounding factors. Additionally, levels of heterogeneity were considerable for some outcomes of interest. Results from this meta-analysis provide evidence for the health benefits of walnuts on blood lipids. Walnuts possibly reduce the risk of CVD; thus, they can be successfully added to a dietary pattern to enhance health benefits.
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