The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets
Meuronen T, Lankinen MA, Kolmert J, de Mello VD, Sallinen T, Ågren J, Virtanen KA, Laakso M, Wheelock CE, Pihlajamäki J, Schwab U
Molecular nutrition & food research · 7 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Itä-Suomen Yliopisto
- Gobierno
- Academy of Finland
- Organización sin fines de lucro
- Suomen Kulttuurirahasto
- Organización sin fines de lucro
- Hjärt-Lungfonden
- Organización sin fines de lucro
- Pohjois-Savon Rahasto
- Subvenciones
- Hjärt-Lungfonden (20200693); Academy of Finland (321428); Hjärt-Lungfonden (#20210519); Academy of Finland (309311); Hjärt-Lungfonden (HLF 20210519)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-11-11 · Mol Nutr Food Res · vol. 66 · número 24 · pág. e2200351
- Editorial
- Wiley
- Citado
- 9 citas · más que el 73% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Nutrition, Genetics, and Disease · Lipid metabolism and biosynthesis
- Palabras clave
- fatty acid desaturase, alpha-linolenic acid, linoleic acid, dietary polyunsaturated fatty acids, plasma lipid profile, arachidonic acid, eicosapentaenoic acid, cyclooxygenase metabolites, gene-diet interaction
- MeSH
- humans, fatty acid desaturases, alpha-linolenic acid, fatty acids, fatty acids, unsaturated, linoleic acid, diet, genotype, polymorphism, single nucleotide
11 autores
- Topi Meuronen🇫🇮 · autor de correspondenciaUniversity of Turku; University of Eastern Finland
- Maria Anneli Lankinen🇫🇮University of Eastern Finland
- Johan Kolmert🇸🇪Karolinska Institutet
- Vanessa D. de Mello🇫🇮University of Eastern Finland
- Taisa Sallinen🇫🇮University of Eastern Finland
- Jyrki Ågren🇫🇮University of Eastern Finland
- Kirsi A. Virtanen🇫🇮University of Eastern Finland; Kuopio University Hospital
- Markku Laakso🇫🇮University of Eastern Finland; Kuopio University Hospital
- Craig E. Wheelock🇸🇪🇯🇵Karolinska University Hospital; Gunma University; Karolinska Institutet
- Jussi Pihlajamäki🇫🇮University of Eastern Finland; Kuopio University Hospital
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non-communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.
Methods and results
Participants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha-linolenic acid (ALA, 5 percent of energy (E-%)) or a high linoleic acid (LA, 10 E-%) diet during an 8-week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA-derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high-LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high-ALA diet increased the concentration of plasma ALA and its cytochrome P450-derived epoxides and dihydroxys, and cyclooxygenase-derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono- and dihydroxys increased only in TT genotype carriers.
Conclusions
These findings suggest the potential for genotype-based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
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