Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial
Bath PM, Skinner CJC, Bath CS, Woodhouse LJ, Korovesi AAK, Long H, Havard D, Coleman CM, England TJ, Leyland V, Lim WS, Montgomery AA, Royal S, Avery A, Webb AJ, Gordon AL, for BEET-Winter Investigators
European geriatric medicine · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Nottingham
- Universidad u hospital
- NIHR Nottingham Biomedical Research Centre
- Gobierno
- NIHR Senior Investigator Award
- Gobierno
- National Institute for Health Research (NIHR)
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute for Health and Care Research (NIHR203798)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-11-16 · Eur Geriatr Med · vol. 13 · número 6 · págs. 1343–1355
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Geriatric Care and Nursing Homes · Nitric Oxide and Endothelin Effects · Nutrition and Health Studies
- Palabras clave
- nitrate supplementation, beetroot juice, nitric oxide, nursing home residents, winter infections, COVID-19 pandemic, urinary nitrate, infection control, hospitalization, mortality, nursing homes, trial feasibility, recruitment (clinical trials)
- MeSH
- humans, beta vulgaris, nitrates, nitrogen oxides, feasibility studies, dietary supplements, aged, 80 and over, pandemics, covid-19, covid-19 vaccines
17 autores
- Philip M. Bath🇬🇧 · autor de correspondenciaNottingham University Hospitals NHS Trust; University of Nottingham
- Cameron J. C. Skinner🇬🇧University of Nottingham
- Charlotte S. Bath🇬🇧University of Nottingham
- Lisa Jane Woodhouse🇬🇧University of Nottingham
- Anastasia Areti Kyriazopoulou Korovesi🇬🇧University of Nottingham
- Hongjiang Long🇬🇧University of Nottingham
- Diane Havard🇬🇧University of Nottingham
- Christopher M. Coleman🇬🇧University of Nottingham
- Timothy J. England🇬🇧University of Nottingham; University Hospitals of Derby and Burton NHS Foundation Trust
- Valerie Leyland
- Wei Shen Lim🇬🇧Nottingham University Hospitals NHS Trust
- Alan A. Montgomery🇬🇧University of Nottingham
- Simon Royal🇬🇧University of Nottingham
- Amanda Avery🇬🇧University of Nottingham
- Andrew J. Webb🇬🇧St Thomas' Hospital; King's College London; British Heart Foundation
- Adam Lee Gordon🇬🇧University of Nottingham
- for BEET-Winter Investigators
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents.
Methods
We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events.
Results
Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7-12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18-175] v 18 [10-50] mg/L, difference 25 [0-90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common.
Conclusions
Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required.
Trial registration
ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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