Dietary cholesterol consumption and incidence of type 2 diabetes mellitus: A dose-response meta-analysis of prospective cohort studies
Li Y, Pei H, Zhou C, Lou Y
Nutrition, metabolism, and cardiovascular diseases : NMCD · 9 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Peking Union Medical College
- Gobierno
- Fundamental Research Funds for the Central Universities
- Subvenciones
- National Natural Science Foundation of China (81970290); Fundamental Research Funds for the Central Universities (2017320009); National Natural Science Foundation of China (81760096)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2022-08-31 · Nutr Metab Cardiovasc Dis · vol. 33 · número 1 · págs. 2–10
- Editorial
- Elsevier BV
- Citado
- 14 citas · más que el 61% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Consumer Attitudes and Food Labeling
- Palabras clave
- Medicine, Subgroup analysis, Prospective cohort study, Meta-analysis, Type 2 Diabetes Mellitus, Incidence (geometry), Internal medicine, Type 2 diabetes, Confidence interval, Relative risk, Random effects model, Diabetes mellitus, Cohort study, Demography, Endocrinology, Mathematics
- MeSH
- humans, diabetes mellitus, type 2, cholesterol, dietary, incidence, risk factors, prospective studies
4 autores
- Yuehua Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Hanjun Pei🇨🇳Baotou Medical College
- Chenghui Zhou🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Ying Lou🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
The purpose of this meta-analysis was to evaluate the dose-response relationship between dietary cholesterol (DC) consumption and the incidence of type 2 diabetes mellitus (T2DM).
Methods and results
Prospective studies with the endpoint of T2DM were included. The Random-effect model weighted by inverse variance was used. Meta-regression and subgroup analyses were conducted to explore the potential sources of heterogeneity by specified study characteristics. Restricted cubic splines regression models were used to estimate the dose-response relationship. 11 prospective studies comprising of 355 230 subjects were included. Compared to lowest DC consumption, highest DC consumption was associated with an increased risk of T2DM (RR 1.15, 95% CI 1.03 to 1.28, P = 0.012; chi-squared = 31.41, I-squared 58.6%, P heterogeneity = 0.003). Subgroup analyses have shown that this positive association was more evident in western countries than in eastern countries (RR 1.19, 95% CI 1.06 to 1.36 VS 1.34, 95% CI 0.84 to 1.29; P subgroup difference = 0.02). For 100 mg/d increment in DC intake, the pooled RR was 1.05, (95% CI 1.04 to 1.07, Plinearity = 0.000, Pnonlinearity = 0.02), 1.06 (95% CI 1.04 to 1.07, Plinearity=0.000), and 1.01 (95% CI 0.98 to 1.05, Plinearity = 0.525) for the incidence of T2DM, in western and eastern countries, respectively.
Conclusions
Our study suggests that there is a positive dose-response association between DC consumption and the incidence of T2DM, especially in western countries.
Systematic review registration
PROSPERO CRD42020216318.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.