Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation
Abe I, Oguri Y, Verkerke ARP, Monteiro LB, Knuth CM, Auger C, Qiu Y, Westcott GP, Cinti S, Shinoda K, Jeschke MG, Kajimura S
Developmental cell · 52 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Howard Hughes Medical Institute
- Organización sin fines de lucro
- Uehara Memorial Foundation
- Organización sin fines de lucro
- Japan Heart Foundation
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of California, San Diego
- Gobierno
- Japan Society for the Promotion of Science
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007516); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK135043); Japan Society for the Promotion of Science (23K24766); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK133948); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK125281); National Institute of Diabetes and Digestive and Kidney Diseases (K08 DK132413); Uehara Memorial Foundation (T32DK007516); National Institute of Diabetes and Digestive and Kidney Diseases (DP1 DK126160); National Institute of General Medical Sciences (R01 GM133961); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK097441); National Institutes of Health (1s10od028635-01); National Institutes of Health (#R01GM133961); National Institutes of Health (RO1DK125281); National Institutes of Health (DP1DK126160)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2022-12-01 · Dev Cell · vol. 57 · número 23 · págs. 2623–2637.e8
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 97% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 78 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Adipose Tissue and Metabolism · Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Biology, Progenitor cell, Cell biology, Linoleic acid, CD36, Adipose tissue, Lipolysis, Arachidonic acid, Endocrinology, Internal medicine, Fatty acid, Biochemistry, Stem cell, Receptor
- MeSH
- animals, humans, mice, linoleic acid, cell proliferation, adipose tissue, beige
12 autores
- Ichitaro Abe🇺🇸🇯🇵Beth Israel Deaconess Medical Center; Harvard University; Oita University
- Yasuo Oguri🇯🇵Kyoto University
- Anthony R.P. Verkerke🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Lauar de Brito Monteiro🇨🇦Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital; Sunnybrook Research Institute
- Carly M. Knuth🇨🇦Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital; Sunnybrook Research Institute
- Christopher Auger🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Yunping Qiu🇺🇸Albert Einstein College of Medicine
- Gregory P. Westcott🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Saverio Cinti🇮🇹Marche Polytechnic University
- Kosaku Shinoda🇺🇸Albert Einstein College of Medicine
- Marc G. Jeschke🇨🇦University of Toronto; Sunnybrook Hospital; Sunnybrook Research Institute
- Shingo Kajimura🇺🇸 · autor de correspondenciaBeth Israel Deaconess Medical Center; Howard Hughes Medical Institute; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-derived linoleic acid triggers beige progenitor cell proliferation following cold acclimation, β3-adrenoceptor activation, and burn injury. A subset of adipocyte progenitors, as marked by cell surface markers PDGFRα or Sca1 and CD81, harbored cristae-rich mitochondria and actively imported linoleic acid via a fatty acid transporter CD36. Linoleic acid not only was oxidized as fuel in the mitochondria but also was utilized for the synthesis of arachidonic acid-derived signaling entities such as prostaglandin D2. Oral supplementation of linoleic acid was sufficient to stimulate beige progenitor cell proliferation, even under thermoneutral conditions, in a CD36-dependent manner. Together, this study provides mechanistic insights into how diverse pathophysiological stimuli, such as cold and burn injury, promote de novo beige fat biogenesis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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