Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study
Luo J, Zhang C, Zhao Q, Wu W, Liang X, Xiao Z, Mortimer JA, Borenstein AR, Dai Q, Ding D
Alzheimer's & dementia (New York, N. Y.) · 15 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Shanghai Hospital Development Center
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- Shanghai Hospital Development Center (SHDC2020CR4007); National Natural Science Foundation of China (81773513); National Institute on Aging (R21 AG028182); National Natural Science Foundation of China (82071200)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-01-01 · Alzheimers Dement (N Y) · vol. 8 · número 1 · pág. e12362
- Editorial
- Elsevier BV
- Citado
- 21 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Trace Elements in Health
- Palabras clave
- Dementia, Hazard ratio, Medicine, Calcium, Magnesium, Internal medicine, Confidence interval, Prospective cohort study, Incidence (geometry), Chemistry, Disease
10 autores
- Jianfeng Luo🇨🇳🇰🇷Fudan University; Ministry of Education
- Chenbo Zhang🇨🇳🇰🇷Fudan University; Ministry of Education
- Qianhua Zhao🇨🇳Fudan University; Huashan Hospital
- Wanqing Wu🇨🇳Fudan University; Huashan Hospital
- Xiaoniu Liang🇨🇳Fudan University; Huashan Hospital
- Zhenxu Xiao🇨🇳Fudan University; Huashan Hospital
- James A. Mortimer🇺🇸University of South Florida
- Amy R. Borenstein🇺🇸University of California San Diego; Human Longevity (United States)
- Qi Dai🇺🇸Vanderbilt University Medical Center
- Ding Ding🇨🇳 · autor de correspondenciaFudan University; Huashan Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Calcium (Ca), magnesium (Mg), or the calcium to magnesium (Ca:Mg) ratio may affect the risk of dementia via complex mechanisms. The aim of this study was to evaluate the association of dietary Ca, Mg, and Ca:Mg ratio with dementia risk at the prospective phase of the Shanghai Aging Study.
Methods
We analyzed data from 1565 dementia-free participants living in an urban community who had measurements of dietary Ca and Mg intake derived from a food frequency questionnaire at baseline and incident dementia during follow-up.
Results
Over the 5-year follow-up, 162 (10.4%) participants were diagnosed with incident dementia by Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria. Participants with the lowest tertile of dietary Ca (267.5 mg/day was related to an increased risk for dementia (adjusted hazard ratio: 3.97, 95% confidence interval: 1.29-12.25).
Conclusions
Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia.
Highlights
Participants with the lowest tertile of dietary calcium (Ca) and magnesium (Mg) had the highest incidence rates of dementia.In the subgroup with Ca:Mg ratios ≤1.69, Mg intake >267.5 mg/day was related to an increased risk for dementia.Balance of Ca to Mg in diet may be critical to the relationship between Mg intake and risk of dementia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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