High-fat low-carbohydrate enteral feeding enriched with olive oil and acute respiratory failure: A double-blind, randomized, controlled trial
Nourmohammadi M, Moradi Moghdam O, Niakan Lahiji M, Vahdat Shariatpanahi Z
Clinical nutrition ESPEN · 5 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-10-31 · Clin Nutr ESPEN · vol. 52 · págs. 144–150
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 71% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Respiratory Support and Mechanisms · Nosocomial Infections in ICU
- Palabras clave
- low-carbohydrate high-fat diet, enteral nutrition, olive oil, sunflower oil, acute respiratory failure, weaning from mechanical ventilation, total antioxidant capacity, gastrointestinal complications, gastric residual volume, diarrhea
- MeSH
- humans, respiratory insufficiency, carbohydrates, c-reactive protein, antioxidants, enteral nutrition, olive oil, sunflower oil
4 autores
- Mahdieh Nourmohammadi🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Omid Moradi Moghdam🇮🇷 · autor de correspondenciaIran University of Medical Sciences; Rasool Akram Hospital
- Mohammad Niakan Lahiji🇮🇷 · autor de correspondenciaIran University of Medical Sciences; Rasool Akram Hospital
- Zahra Vahdat Shariatpanahi🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
The study evaluated the impact of two types of high fat diet on the outcomes of acute pulmonary failure.
Methods
A total of 93 Ventilated acute pulmonary failure patients with enteral feeding were assigned randomly to the control group with carbohydrate-based formula (protein: 20%, fat: 30%, carbohydrate: 50%) and two study groups with fat-based formula, including group A (protein: 20%, In equal proportions of olive and sunflower oil 45%, charbohydrate:35%) and group B (protein: 20%, sunflower oil:45%, charbohydrate:35%). The diets were prescribed for 14 days.
Results
In each group, 16 patients completed the study. The PaCO2 decreased significantly in the study group A compared with the control group at weaning. The risk of separation from mechanical ventilation during study period was eight times higher in the study group A than the control group. On day 10 of intervention, serum hs-CRP decreased significantly in the control group and the study group A compared to the baseline. Serum concentration of total antioxidant capacity was increased significantly in the study group A on day 10 of the intervention, but in the other two groups it was reduced. Gastrointestinal complications, including diarrhea and high gastric residual volume, were not different between the groups.
Conclusion
With a fat-based diet high in olive oil, more patients were weaned during the study period. This diet reduced the PaCo2 at weaning, reduced the serum level of hs-CRP, and increased the serum level of total antioxidant capacity concentration. Fat-based diet high in sunflower oil did not have any beneficial effects on outcomes.
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