Detections of organophosphate and pyrethroid insecticide metabolites in urine and sweat obtained from women during infrared sauna and exercise: A pilot crossover study
Hussain J, Cohen M, O'Malley CJ, Mantri N, Li Y, Mueller JF, Greaves R, Wang X
International journal of hygiene and environmental health · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- RMIT University
- Universidad u hospital
- University of Queensland
- Organización sin fines de lucro
- Minderoo Foundation
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- University of Queensland (31342); RMIT University (21191); University of Queensland (12618000679280)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2022-12-12 · Int J Hyg Environ Health · vol. 248 · pág. 114091
- Editorial
- Elsevier BV
- Citado
- 2 citas · más que el 44% de estudios similares · 0.1× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pesticide Exposure and Toxicity · Pesticide Residue Analysis and Safety · Effects and risks of endocrine disrupting chemicals
- Palabras clave
- organophosphate insecticides, pyrethroid insecticides, insecticide metabolites, human sweat, urinary biomonitoring, infrared sauna, physical activity, cycling, 3-phenoxybenzoic acid, 3,5,6-trichloro-2-pyridinol, pesticide exposure
- MeSH
- sweat, humans, benzoates, pyrethrins, pesticides, insecticides, steam bath, cross-over studies, environmental exposure, female, organophosphates
8 autores
- Joy N. Hussain🇦🇺 · autor de correspondenciaRMIT University
- Marc Maurice Cohen🇦🇺Extreme Wellness Institute
- Cindy J. O’Malley🇦🇺RMIT University
- Nitin L. Mantri🇦🇺RMIT University
- Yan Li🇦🇺The University of Queensland
- Jochen F. Mueller🇦🇺The University of Queensland
- Ronda F. Greaves🇦🇺The University of Melbourne; Victorian Clinical Genetics Services; Murdoch Children's Research Institute; RMIT University
- Xianyu Wang🇦🇺The University of Queensland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Synthetic pesticides such as organophosphates and pyrethroids are commonly used worldwide yet the metabolic and long-term human health effects of these environmental exposures are unclear. Urinary detections of metabolites involving both classes of insecticides have been documented in various global populations. However, reports documenting similar detections in human sweat are sparse. In this study, the concentrations of four insecticide metabolites were measured using liquid chromatography coupled with tandem mass spectrometry in repeated sweat and urine collections (n = 85) from 10 women undergoing three interventions (control, infrared sauna and indoor bicycling) within a single-blinded randomised crossover trial. The Friedman test with post-hoc two-way analysis of variance, the related-samples Wilcoxon signed rank test and the Spearman's rank-order correlation test were used to analyse the results. Organophosphate metabolites were detected in 84.6% (22/26) and pyrethroids in 26.9% (7/26) of the collected sweat samples (pooled per individual, per intervention). Urinary concentrations of three of the four metabolites marginally increased after infrared sauna bathing: 3,5,6-trichloro-2-pyridinol (z = 2.395, p = 0.017); 3-phenoxybenzoic acid (z = 2.599, p = 0.009); and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (z = 2.090, p = 0.037). Urinary 3-phenoxybenzoic acid also increased after exercise (z = 2.073, p = 0.038) and demonstrated the most temporal variability (days to weeks) of any of the urinary metabolites. Definitive sweat/urine correlations were not demonstrated. These results indicate metabolites from organophosphate and pyrethroid pesticides can be detected in human sweat and this raises intriguing questions about perspiration and its role in the metabolism and excretion of synthetic pesticides.
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