Time-restricted eating did not alter insulin sensitivity or β-cell function in adults with obesity: A randomized pilot study
Bantle AE, Lau KJ, Wang Q, Malaeb S, Harindhanavudhi T, Manoogian ENC, Panda S, Mashek DG, Chow LS
Obesity (Silver Spring, Md.) · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIA NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute on Aging (R01AG065569); National Center for Advancing Translational Sciences ((UL1-TR002494)); National Institute of Diabetes and Digestive and Kidney Diseases (DK124484); National Institute on Aging (AG065569); National Institute of Diabetes and Digestive and Kidney Diseases (DK118278); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK124484); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK115906); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007203)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-12-14 · Obesity (Silver Spring) · vol. 31 · número S1 · págs. 108–115
- Editorial
- Wiley
- Citado
- 17 citas · más que el 83% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Bariatric Surgery and Outcomes
- Palabras clave
- time-restricted eating, insulin sensitivity, beta-cell function, overweight, insulin secretion, type 2 diabetes prevention, prediabetes, eating window, oral glucose tolerance test, QUICKI, insulinogenic index, disposition index
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, obesity, insulin, blood glucose, pilot projects, adult, middle aged, female, male, overweight
9 autores
- A. Bantle🇺🇸 · autor de correspondenciaUniversity of Minnesota
- Kheng Joe Lau
- Qi Wang🇺🇸University of Minnesota
- Samar Malaeb🇺🇸Park Nicollet Health Services; Park Nicollet Clinic
- Tasma Harindhanavudhi🇺🇸University of Minnesota
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Douglas G. Mashek🇺🇸University of Minnesota
- Lisa Senye Chow🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Decreased insulin sensitivity and impairment of β-cell function predate and predict development of type 2 diabetes mellitus. Time-restricted eating (TRE) might have a benefit for these parameters. The objective of this pilot study was to investigate this possibility.
Methods
Secondary analysis of a randomized controlled trial comparing 12 weeks of TRE (8-hour eating window) to unrestricted eating (non-TRE) was performed. Participants were adults with overweight or obesity and without diabetes. Two-hour oral glucose tolerance testing was performed at baseline and end-intervention. Glucose tolerance test-derived measures of insulin sensitivity, insulin secretion, and β-cell function were compared between groups.
Results
Participants (17 women/3 men with mean [SD] age 45.5 [12.1] years and BMI 34.1 [7.5] kg/m2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11) or non-TRE (n = 9). The quantitative insulin sensitivity check index (QUICKI), Stumvoll index, Avignon index, insulinogenic index, insulin area under the curve/glucose area under the curve, and oral disposition index did not differ between the TRE and non-TRE groups at end-intervention.
Conclusions
In adults with overweight or obesity and without diabetes, TRE did not significantly alter insulin sensitivity, insulin secretion, or β-cell function over a 12-week intervention. Whether TRE is beneficial in adults with prediabetes or type 2 diabetes mellitus warrants further investigation.
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