A systematic review and meta-analysis of almond effect on C-reactive protein and interleukin-6 in adults
Hariri M, Amirkalali B, Baradaran HR, Gholami A
Complementary therapies in medicine · 5 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Neyshabur University of Medical Sciences
- Subvenciones
- Neyshabur University of Medical Sciences (40004017)
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-12-16 · Complement Ther Med · vol. 72 · pág. 102911
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 35% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- almond consumption, C-reactive protein, interleukin-6, inflammation, serum inflammatory markers, nut intake, dietary intervention
- MeSH
- humans, c-reactive protein, interleukin-6, time factors, dietary supplements, adult, biomarkers, prunus dulcis
4 autores
- Mitra Hariri🇮🇷University of Neyshabur; Neyshabur University of Medical Sciences
- Bahareh Amirkalali🇮🇷Iran University of Medical Sciences
- Hamid Reza Baradaran🇮🇷Iran University of Medical Sciences
- Ali Gholami🇮🇷 · autor de correspondenciaUniversity of Neyshabur; Neyshabur University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The previous articles have shown that the almond might reduce the serum concentration of inflammatory mediators. Therefore, the studies reported in this article aimed to assess the almond effect on serum concentration of C-reactive protein (CRP) and interleukin-6 (IL-6) in adults.
Method and materials
To find the related English-language studies, an electronic search was run in databases including Web of Science, PubMed, SCOPUS, ClinicalTrials.gov, and Cochrane library with no time limit (up to August 2022). The effect sizes were calculated based on the mean changes for both intervention and comparison groups. DerSimonian and Laird random-effects model was used to determine the summary of overall effects and their heterogeneity. Cochran's Q test and I-squared statistic were used to explore the statistical heterogeneity.
Results
In total, eleven studies were included in this study. The overall estimate indicated that the almond consumption had no significant effect on serum CRP level (weighted mean difference (WMD) = -0.28 mg/l, 95 % confidence interval (CI): - 0.81, 0.25; p = 0.29). Regarding IL-6, almond consumption significantly decreased serum IL-6 level (WMD = -0.1 pg/ml, 95 % CI: -0.15, -0.05; p < 0.001).
Conclusion
The overall results support the beneficial effects of almond consumption on serum concentration of IL-6; but even so, our study revealed that the almond consumption non-significantly reduced serum concentration of CRP. We still need more well-designed trials to confirm the beneficial effects of almond.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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