Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial
Parr EB, Kouw IWK, Wheeler MJ, Radford BE, Hall RC, Senden JM, Goessens JPB, van Loon LJC, Hawley JA
Obesity (Silver Spring, Md.) · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-12-22 · Obesity (Silver Spring) · vol. 31 · número S1 · págs. 116–126
- Editorial
- Wiley
- Citado
- 27 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Muscle metabolism and nutrition · Circadian rhythm and melatonin
- Palabras clave
- Medicine, Overweight, Animal science, Internal medicine, Lean body mass, Body mass index, Obesity, Endocrinology, Randomized controlled trial, Body weight, Biology
- MeSH
- muscle, skeletal, humans, obesity, blood glucose, blood glucose self-monitoring, diet, adult, middle aged, male
9 autores
- Evelyn B. Parr🇦🇺 · autor de correspondenciaAustralian Catholic University
- Imre W. K. Kouw🇦🇺Australian Catholic University
- Michael J. Wheeler🇦🇺Australian Catholic University
- Bridget E. Radford🇦🇺Australian Catholic University
- Rebecca C. Hall🇦🇺Australian Catholic University
- Joan M. Senden🇳🇱Maastricht University Medical Centre; Maastricht University
- Joy P. B. Goessens🇳🇱Maastricht University Medical Centre; Maastricht University
- Luc J. C. van Loon🇳🇱🇦🇺Maastricht University Medical Centre; Maastricht University; Australian Catholic University
- John A. Hawley🇦🇺Australian Catholic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.
Methods
A total of 18 healthy males (age 46 ± 5 years; BMI: 30 ± 2 kg/m2 ) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual-energy x-ray absorptiometry).
Results
There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24-hour total area under the curve was reduced following TRE (-578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: -1.6 ± 0.9 and CON: -1.1 ± 0.7 kg; p < 0.001) with no differences between groups (p = 0.22). Lean mass loss was greater following TRE compared with CON (-1.0 ± 0.7 vs. -0.2 ± 0.5 kg, respectively; p = 0.01).
Conclusion
Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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