Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial
Ezpeleta M, Gabel K, Cienfuegos S, Kalam F, Lin S, Pavlou V, Song Z, Haus JM, Koppe S, Alexandria SJ, Tussing-Humphreys L, Varady KA
Cell metabolism · 143 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-020572); National Cancer Institute (#T32CA193193); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119783); National Institutes of Health (R01 DK119783)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-12-21 · Cell Metab · vol. 35 · número 1 · págs. 56–70.e3
- Editorial
- Cell Press
- Citado
- 169 citas · más que el 100% de estudios similares · 19.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 112 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Dietary Effects on Health · Diet, Metabolism, and Disease
- Palabras clave
- non-alcoholic fatty liver disease, alternate-day fasting, intermittent fasting, aerobic exercise, hepatic steatosis, intrahepatic triglyceride, obesity, insulin sensitivity, lifestyle intervention, alanine aminotransferase, hepatokines
- MeSH
- liver, humans, body weight, triglycerides, exercise, fasting, adult, aged, middle aged, female, male, young adult, non-alcoholic fatty liver disease
12 autores
- Mark Ezpeleta🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Sofia Cienfuegos🇺🇸University of Illinois Chicago
- Faiza Kalam🇺🇸University of Illinois Chicago
- Shuhao Lin🇺🇸University of Illinois Chicago
- Vasiliki Pavlou🇺🇸University of Illinois Chicago
- Zhenyuan Song🇺🇸University of Illinois Chicago
- Jacob M. Haus🇺🇸University of Michigan
- Sean Koppe🇺🇸University of Illinois Chicago
- Shaina J. Alexandria🇺🇸Northwestern University
- Lisa Marie Tussing-Humphreys🇺🇸University of Illinois Chicago
- Krista A Varady🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Innovative non-pharmacological lifestyle strategies to treat non-alcoholic fatty liver disease (NAFLD) are critically needed. This study compared the effects of alternate day fasting (ADF) combined with exercise to fasting alone, or exercise alone, on intrahepatic triglyceride (IHTG) content. Adults with obesity and NAFLD (n = 80, 81% female, age: 23-65 years) were randomized to 1 of 4 groups for 3 months: combination of ADF (600 kcal/2,500 kJ "fast day" alternated with an ad libitum intake "feast day") and moderate-intensity aerobic exercise (5 session per week, 60 min/session); ADF alone; exercise alone; or a no-intervention control group. By month 3, IHTG content was significantly reduced in the combination group (-5.48%; 95% CI, -7.77% to -3.18%), compared with the exercise group (-1.30%; 95% CI, -3.80% to 1.20%; p = 0.02) and the control group (-0.17%; 95% CI, -2.17% to 1.83%; p < 0.01) but was not significantly different versus the ADF group (-2.25%; 95% CI, -4.46% to -0.04%; p = 0.05). Body weight, fat mass, waist circumference, and alanine transaminase (ALT) levels significantly decreased, while insulin sensitivity significantly increased in the combination group compared with the control group. Lean mass, aspartate transaminase (AST), HbA1c, blood pressure, plasma lipids, liver fibrosis score, and hepatokines (fetuin-A, FGF-21, and selenoprotein P) did not differ between groups. Combining intermittent fasting with exercise is effective for reducing hepatic steatosis in patients with NAFLD but may offer no additional benefit versus fasting alone.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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