Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease
Pekas EJ, Anderson CP, Park SY
Microvascular research · 6 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIA NIH HHS
- Gobierno
- NICHD NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (P20GM109090); National Institute on Aging (R01AG077803); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD106911)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2022-12-20 · Microvasc Res · vol. 146 · pág. 104469
- Editorial
- Elsevier BV
- Citado
- 9 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Peripheral Artery Disease Management · Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects
- Palabras clave
- peripheral arterial disease, dietary nitrate, beetroot juice, autonomic nervous system, heart rate variability, 6-minute walk distance, pain-free walking distance, post-exercise recovery, claudication, nitric oxide
- MeSH
- muscle, skeletal, humans, intermittent claudication, nitrates, cross-over studies, dietary supplements, hemodynamics, peripheral arterial disease
3 autores
- Elizabeth J. Pekas🇺🇸University of Nebraska at Omaha
- Cody P. Anderson🇺🇸University of Nebraska at Omaha
- Song‐Young Park🇺🇸 · autor de correspondenciaUniversity of Nebraska at Omaha
Resumen
El texto original del estudio, en el idioma en que se publicó.
Peripheral artery disease (PAD) is an atherosclerotic disease characterized by compromised lower-extremity blood flow that impairs walking ability. We showed that a moderate dose of dietary nitrate in the form of beetroot juice (BRJ, 0.11 mmol/kg) can improve macrovascular function and maximal walking distance in patients with PAD. However, its impacts on the microcirculation and autonomic nervous system have not been examined. Therefore, we investigated the impacts of this dose of dietary nitrate on skeletal muscle microvascular function and autonomic nervous system function and further related these measurements to 6-min walking distance, pain-free walking distance, and exercise recovery in patients with PAD. Patients with PAD (n = 10) ingested either BRJ or placebo in a randomized crossover design. Heart rate variability, skeletal muscle microvascular function, and 6-min walking distance were performed pre- and post-BRJ and placebo. There were significant group × time interactions (P 0.05) in heart rate variability or pain-free walking distance were noted. The BRJ group demonstrated improved skeletal muscle microvascular function (∆ 22.1 ± 7.5 %·min-1), longer 6-min walking distance (Δ 37.5 ± 9.1 m), and faster recovery post-exercise (Δ -15.3 ± 4.2 s). Furthermore, changes in skeletal muscle microvascular function were positively associated with changes in 6-min walking distance (r = 0.5) and pain-free walking distance (r = 0.6). These results suggest that a moderate dose of dietary nitrate may support microvascular function, which is related to improvements in walking distance and claudication in patients with PAD.
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