Clinically Significant Axial Shortening in Myopic Children After Repeated Low-Level Red Light Therapy: A Retrospective Multicenter Analysis
Wang W, Jiang Y, Zhu Z, Zhang S, Xuan M, Chen Y, Xiong R, Bulloch G, Zeng J, Morgan IG, He M
Ophthalmology and therapy · 37 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Fundamental Research Funds of the State Key Laboratory of Ophthalmology
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-01-07 · Ophthalmol Ther · vol. 12 · número 2 · págs. 999–1011
- Editorial
- Adis, Springer Healthcare
- Citado
- 49 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Palabras clave
- Medicine, Dioptre, Visual acuity, Ophthalmology
11 autores
- Wei Wang🇨🇳Sun Yat-sen University
- Yu Jiang🇨🇳Sun Yat-sen University
- Zhuoting Zhu🇨🇳Sun Yat-sen University
- Shiran Zhang🇨🇳Sun Yat-sen University
- Meng Xuan🇨🇳Sun Yat-sen University
- Yanping Chen🇨🇳Sun Yat-sen University
- Ruilin Xiong🇨🇳Sun Yat-sen University
- Gabriella Bulloch🇦🇺The University of Melbourne; Centre for Eye Research Australia
- Junwen Zeng🇨🇳Sun Yat-sen University
- Ian George Morgan🇦🇺Australian National University
- Mingguang He🇨🇳🇦🇺 · autor de correspondenciaSun Yat-sen University; The University of Melbourne; Centre for Eye Research Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Myopia is recognized as a progressive eye disease. The aim of this study was to evaluate the frequency and associated factors of clinically significant axial length (AL) shortening among myopic children following repeated low-level red light (RLRL) therapy.
Methods
The clinical data that were collected for the myopic children aged 3-17 years who received an RLRL therapy delivered by home-use desktop light device that emitted light at 650 nm for at least 1 year, were reviewed. The clinical data included AL, spherical equivalent refraction (SER), and visual acuity measured at baseline and follow-up. The primary outcomes were frequency of AL shortening of > 0.05 mm, > 0.10 mm, and > 0.20 mm per year, and associated factors of AL shortening per year.
Results
A total of 434 myopic children with at least 12 months of follow-up data were included. The mean age of participants was 9.7 (2.6) years with SER of -3.74 (2.60) diopters. There were 115 (26.50%), 76 (17.51%), and 20 (4.61%) children with AL shortening based on cutoffs of 0.05 mm/year, 0.10 mm/year, and 0.20 mm/year, respectively. In the multivariable model, AL shortening was significantly associated with older baseline age, female gender, and longer baseline AL or greater spherical equivalent refraction (all P < 0.05). Among AL shortened eyes, the mean AL difference (standard deviation, SD) was -0.142 (0.094) mm/year. Greater AL shortening was observed among children who were younger and had longer baseline AL (all P < 0.05).
Conclusions
More than a quarter of children had AL shortening > 0.05 mm following RLRL therapy, and the overall mean AL change was -0.142 mm/year. Further studies should explore the mechanisms underlying AL shortening.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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