Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial
Gholizadeh-Moghaddam M, Ghasemi-Tehrani H, Askari G, Jaripur M, Clark CCT, Rouhani MH
Health science reports · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-12-29 · Health Sci Rep · vol. 6 · número 1 · pág. e1013
- Editorial
- Wiley
- Citado
- 15 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Ovarian function and disorders · Preterm Birth and Chorioamnionitis
- Palabras clave
- Polycystic ovary, Hyperandrogenism, hirsutism, Medicine, Randomized controlled trial, Placebo, Internal medicine, Endocrinology, Diabetes mellitus, Insulin resistance
6 autores
- Mahsa Gholizadeh‐Moghaddam🇮🇷Isfahan University of Medical Sciences
- Hatav Ghasemi Tehrani🇮🇷Isfahan University of Medical Sciences
- Gholamreza Askari🇮🇷Isfahan University of Medical Sciences
- Mahsima Jaripur🇮🇷Isfahan University of Medical Sciences
- Cain C. T. Clark🇬🇧Coventry University
- Mohammad Hossein Rouhani🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women, which causes numerous symptoms in women. The relationship of many micronutrients with this syndrome has been investigated. This study was conducted to examine the effects of magnesium supplementation on hyperandrogenism, hirsutism, and sleep quality in women with PCOS.
Methods
In this parallel randomized clinical trial, 64 women with PCOS were randomly assigned to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. Patients in the magnesium group received one 250 mg magnesium oxide tablet, per day. Hyperandrogenism, hirsutism, and sleep quality were measured at the beginning and end of the study. This randomized clinical trial was registered at https://www.IRCT.ir (IRCT20130903014551N8).
Results
Magnesium supplementation had no significant effect on hyperandrogenism (p = 0.51 for dehydroepiandrosterone sulfates, p = 0.27 for testosterone), hirsutism (p = 0.23), and sleep quality (p = 0.85) compared with placebo.
Conclusions
The present study showed that a single dose of magnesium supplementation elicited no beneficial effects on the mentioned symptoms in polycystic women. It is possible that the positive effects of magnesium observed in the former studies were due to the synergistic effects of other vitamins or minerals. More studies are needed in this area.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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