Acute Effects of Dietary Nitrate on Central Pressure and Endothelial Function in Hypertensive Patients: A Randomized, Placebo-Controlled Crossover Study
Mattos S, Cunha MR, Marques BC, D El-Rei J, Baião DDS, Paschoalin VMF, Oigman W, Neves MF, Medeiros F
Arquivos brasileiros de cardiologia · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-01-01 · Arq Bras Cardiol · vol. 120 · número 1 · pág. e20220209
- Editorial
- Sociedade Brasileira de Cardiologia (SBC)
- Citado
- 6 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, beetroot juice, hypertension, blood pressure, endothelial function, subendocardial viability ratio, ejection time, post-occlusive reactive hyperemia, microvascular reactivity, myocardial perfusion
- MeSH
- endothelium, humans, hypertension, nitrates, cross-over studies, double-blind method, blood pressure, dietary supplements, aged, middle aged, female
9 autores
- Samanta Souza Mattos🇧🇷Universidade do Estado do Rio de Janeiro
- Michelle Rabello Cunha🇧🇷Universidade do Estado do Rio de Janeiro
- Bianca Cristina Marques🇧🇷Universidade do Estado do Rio de Janeiro
- Jenifer d’El-Rei🇧🇷Universidade do Estado do Rio de Janeiro
- Diego dos Santos Baião🇧🇷Universidade Federal do Rio de Janeiro
- Vânia Margaret Flosi Paschoalin🇧🇷Universidade Federal do Rio de Janeiro
- Wille Oigman🇧🇷Universidade do Estado do Rio de Janeiro
- Mário Fritsch Neves🇧🇷Universidade do Estado do Rio de Janeiro
- Fernanda Medeiros🇧🇷Universidade Federal do Estado do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The diet's inorganic nitrate (NO3-) may provide a physiological substrate for reducing nitrate (NO2-) to NO independent of the endothelium. Studies suggest that inorganic NO3- has beneficial effects on cardiovascular health.
Objective
This study evaluated the acute effects of 500 mL nitrate-rich beetroot juice (BRJ; containing 11.5mmol NO3-) on blood pressure and endothelial function in treated hypertensive patients.
Methods
A randomized, placebo-controlled, crossover study was conducted in treated hypertensive patients (n=37; women=62%) who underwent clinical and nutritional evaluation and assessment of central hemodynamic parameters and microvascular reactivity. The significance level was p<0.05.
Results
The mean age was 59±7 years, and mean systolic and diastolic blood pressures were 142±10/83±9mmHg. There was a significant increase in the subendocardial viability ratio (SEVR; 149±25 vs. 165±30%, p<0.001) and reduction in ejection duration (ED; 37±4 vs. 34±4%, p<0.001) in the beetroot phase but no significant SEVR difference in the control phase. The % increase in perfusion (155 vs. 159 %, p=0.042) was significantly increased in the beetroot phase, which was not observed in the control phase. In the beetroot phase, the change in SEVR showed a significant correlation with the change in the area under the curve of post-occlusive reactive hyperemia (AUC-PORH) (r=0.45, p=0.012). The change in ED showed a significant correlation with the post-intervention perfusion peak (r=-0.37, p=0.031) and AUC-PORH (r=-0.36, p=0.046).
Conclusions
The acute ingestion of BRJ by hypertensive patients resulted in an improvement of endothelial function, which was associated with higher subendocardial viability and performance in myocardial contraction.
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