Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial
Dall RD, Cheung MM, Shewokis PA, Altasan A, Volpe SL, Amori R, Singh H, Sukumar D
Nutrition research (New York, N.Y.) · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Organización sin fines de lucro
- American Heart Association-American Stroke Association
- Subvenciones
- American Heart Association (16SDG27050002)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-12-21 · Nutr Res · vol. 110 · págs. 33–43
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 65% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 81 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Magnesium in Health and Disease · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, magnesium supplementation, combination supplementation, osteocalcin, bone turnover markers, glycemic control, insulin resistance, HOMA-IR, adiponectin, 25-hydroxyvitamin D, alkaline phosphatase, C-terminal telopeptide, obesity, overweight, prediabetes, diabetes mellitus
- MeSH
- humans, insulin resistance, vitamin d deficiency, obesity, magnesium, cholecalciferol, vitamins, vitamin d, osteocalcin, double-blind method, bone remodeling, dietary supplements, female, male, overweight
8 autores
- Rosemary DeLuccia Dall🇺🇸Drexel University
- May M. Cheung🇺🇸City University of New York; Brooklyn College
- Patricia A. Shewokis🇺🇸Drexel University
- Asma Altasan🇺🇸Drexel University
- Stella Lucia Volpe🇺🇸Virginia Tech
- Renee E. Amori🇺🇸St. Luke's University Health Network
- Harpreet Singh🇺🇸The Ohio State University
- Deeptha Sukumar🇺🇸 · autor de correspondenciaDrexel University
Resumen
El texto original del estudio, en el idioma en que se publicó.
High-dose vitamin D supplementation can increase total osteocalcin concentrations that may reduce insulin resistance in individuals at risk for prediabetes or diabetes mellitus. Magnesium is a cofactor in vitamin D metabolism and activation. The purpose of this study was to determine the combined effect of vitamin D and magnesium supplementation on total osteocalcin concentrations, glycemic indices, and other bone turnover markers after a 12-week intervention in individuals who were overweight and obese, but otherwise healthy. We hypothesized that combined supplementation would improve serum total osteocalcin concentrations and glycemic indices more than vitamin D supplementation alone or a placebo. A total of 78 women and men completed this intervention in 3 groups: a vitamin D and magnesium group (1000 IU vitamin D3 and 360 mg magnesium glycinate), a vitamin D group (1000 IU vitamin D3), and a placebo group. Despite a significant increase in serum 25-hydroxyvitamin D concentrations in the vitamin D and magnesium group compared with the placebo group (difference = 5.63; CI, -10.0 to -1.21; P = .001) post-intervention, there were no differences in serum concentrations of total osteocalcin, glucose, insulin, and adiponectin or the homeostatic model assessment of insulin resistance (HOMA-IR) among groups (P > .05 for all). Additionally, total osteocalcin (β = -0.310, P = .081), bone-specific alkaline phosphatase (β = 0.004, P = .986), and C-terminal cross-linked telopeptide (β = 0.426, P = .057), were not significant predictors of HOMA-IR after the intervention. Combined supplementation was not associated with short-term improvements in glycemic indices or bone turnover markers in participants who were overweight and obese in our study. This trial was registered at clinicaltrials.gov (NCT03134417).
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