A Randomized Controlled Trial of Changes in Fluid Distribution across Menstrual Phases with Creatine Supplementation
Moore SR, Gordon AN, Cabre HE, Hackney AC, Smith-Ryan AE
Nutrients · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-01-13 · Nutrients · vol. 15 · número 2 · pág. 429
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 15 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Body Composition Measurement Techniques · Menstrual Health and Disorders
- Palabras clave
- creatine supplementation, creatine monohydrate, menstrual cycle, fluid distribution, total body water, extracellular fluid, intracellular fluid, body mass, hormonal contraception, luteal phase, follicular phase, hydration status, women's health, sports nutrition, bioimpedance spectroscopy
- MeSH
- extracellular fluid, body fluid compartments, humans, body weight, creatine, double-blind method, dietary supplements, female
5 autores
- Sam R. Moore🇺🇸University of North Carolina at Chapel Hill
- Amanda N. Gordon🇺🇸University of North Carolina at Chapel Hill
- Hannah E. Cabre🇺🇸University of North Carolina at Chapel Hill
- Anthony C. Hackney🇺🇸University of North Carolina at Chapel Hill
- Abbie E. Smith‐Ryan🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study examined the effects of creatine (Cr) loading on body mass (BM) and fluid markers of total body water (TBW), extra-cellular fluid (ECF), and intra-cellular fluid (ICF) across the menstrual cycle (MC). Thirty moderately active females, either naturally-menstruating (NM) or using hormonal contraceptives (HC), were randomized to Cr (Cr; 4 × 5 g/day of creatine monohydrate for 5 days; n = 15) or a non-caloric placebo (PL; n = 15) using a double-blind, placebo-controlled design, with a menstrual phase crossover. BM, TBW, ECF, and ICF were measured at pre- and post-supplementation in randomized order of follicular phase (FP; NM: MC days 0−8, HC: inactive pill days) or luteal phase (LP; NM: ≤15 days from next projected cycle start date, HC: active pill days) using bioelectrical impedance spectroscopy. Acute hydration status and salivary estrogen were used as covariates. Change in BM was not different between groups across MC ([PL-Cr] Δ 0.40 ± 0.50 kg; p = 0.427) or between MC phase across groups ([FP-LP] Δ 0.31 ± 0.48 kg; p = 0.528). TBW (p = 0.802), ECF (p = 0.373), and ICF (p = 0.795) were not different between supplement groups at pre-supplementation/FP time points. There were no significant differences between the NM and HC subjects at any time point, for any outcome (p > 0.05). Following LP supplementation, significant changes were observed in TBW (Cr: Δ 0.83 ± 0.38 L, PL: Δ −0.62 ± 0.38 L; p = 0.021), ECF (Cr: Δ 0.46 ± 0.15 L, PL: Δ −0.19 ± 0.15 L; p = 0.013), and ICF (Cr: Δ 0.74 ± 0.23 L, PL: Δ −0.02 ± 0.23 L; p = 0.041). These data demonstrate an increase in all fluid compartments in the LP following Cr loading, without observed alterations in body weight for females.
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