Application of highly ozonated sunflower oil does not improve palatal wound healing: A randomized controlled clinical trial
Loureiro BB, Juber P, Souza AA, Cezario EM, Lima-Junior JC, Fontes KBFC, Soares IF, Zuza EP
Journal of periodontology · 6 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-01-27 · J Periodontol · vol. 94 · número 7 · págs. 858–867
- Editorial
- Wiley
- Citado
- 9 citas · más que el 75% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Medical and Biological Ozone Research · Periodontal Regeneration and Treatments · Laser Applications in Dentistry and Medicine
- Palabras clave
- ozonated sunflower oil, palatal wound healing, free gingival graft, wound size, vascular endothelial growth factor, malondialdehyde, oxidative stress, ozone therapy, periodontal surgery
- MeSH
- palate, humans, vascular endothelial growth factor a, prospective studies, wound healing, sunflower oil
8 autores
- Bruno B. Loureiro🇧🇷Universidade Federal Fluminense
- Paola Juber🇧🇷Universidade Federal Fluminense
- Alessandra Areas e Souza🇧🇷Universidade Federal Fluminense
- Edson Marcus Cezário
- Josué da Costa Lima‐Junior🇧🇷Estácio (Brazil); Fundação Oswaldo Cruz
- KARLA BIANCA FERNANDES DA COSTA FONTES🇧🇷Universidade Federal Fluminense
- Isabela Ferreira Soares🇧🇷Fundação Oswaldo Cruz
- Elizângela Partata Zuza🇧🇷 · autor de correspondenciaUniversidade Federal Fluminense; Universidade Federal de Uberlândia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ozone is a molecule that plays an important role in dentistry, specially for wound healing. The aim of the present study was to clinically and immunologically evaluate the effect of ozonated oil on the healing of palatal wounds.
Methods
This is a prospective, longitudinal, triple-blind, randomized, placebo-controlled clinical trial. The groups were divided as follows: Test group (n = 14): after removal of the free gingival graft (FGG), the palatal wound was treated with ozonized seed sunflower oil with a peroxide index between 510 and 625 meq O2 /kg; Control group (n = 14): after removal of the FGG, the palatal wound was treated with non-ozonated sunflower oil (placebo). The treatments were applied three times a day, for 7 days.
Results
There were no significant differences in the measurements of wound area (mm2 ) between the test and control groups in the different periods evaluated (0, 3, 7, and 14 days; p > 0.05). The intra-group analysis showed a significant decrease in wound size over the course of days (0, 3, 7, and 14 days; p < 0.05). Vascular endothelial growth factor (VEGF; pg/mL) presented a significant reduction at 7 days (p < 0.05) compared to day 3 in the test group (p < 0.05). There was a statistical difference for malondialdehyde (MDA; pg/mL) in the test group between 3 and 7 days post-treatment (p < 0.05) and between test and control groups on the 7th day (p < 0.05).
Conclusions
The application of highly ozonated sunflower oil did not improve the remaining scar area of the palate, decreasing the VEGF and increasing the oxidative stress marker MDA.
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