Financiado en parte por Almond Board of California
Beneficial effects of premeal almond load on glucose profile on oral glucose tolerance and continuous glucose monitoring: randomized crossover trials in Asian Indians with prediabetes
Gulati S, Misra A, Tiwari R, Sharma M, Pandey RM, Upadhyay AD, Sati HC
European journal of clinical nutrition · 11 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
- Subvenciones
- Almond Board of California (RGA-17-MisraA-01)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-02 · Eur J Clin Nutr · vol. 77 · número 5 · págs. 586–595
- Editorial
- Springer Nature
- Citado
- 13 citas · más que el 84% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Food composition and properties · Natural Antidiabetic Agents Studies
- Palabras clave
- almond, prediabetes, postprandial hyperglycemia, glycemic control, glycemic variability, insulin, C-peptide, glucagon, Asian Indians, dietary intervention, continuous glucose monitoring, oral glucose tolerance test, diabetes prevention, nut consumption, fasting blood glucose, HOMA-IR
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, hyperglycemia, glucagon, insulin, c-peptide, glucose, blood glucose, blood glucose self-monitoring, glucose tolerance test, cross-over studies, postprandial period, prunus dulcis
7 autores
- Seema Gulati🇮🇳National Diabetes Obesity and Cholesterol Foundation; Diabetes Foundation
- Anoop Misra🇮🇳 · autor de correspondenciaNational Diabetes Obesity and Cholesterol Foundation; Diabetes Foundation; Fortis C-DOC Hospital
- Rajneesh Tiwari🇮🇳National Diabetes Obesity and Cholesterol Foundation
- Meenu Sharma🇮🇳National Diabetes Obesity and Cholesterol Foundation
- Ravindra Mohan Pandey🇮🇳All India Institute of Medical Sciences
- Ashish Datt Upadhyay🇮🇳All India Institute of Medical Sciences
- Hem Chandra Sati🇮🇳All India Institute of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Rapid conversion from prediabetes to diabetes and frequent postprandial hyperglycemia (PPHG) is seen in Asian Indians. These should be the target of dietary strategies.
Objectives
We hypothesized that dietary intervention of preloading major meals with almonds in participants with prediabetes will decrease overall glycemia and PPHG.
Design
The study included two phases: (1) an oral glucose tolerance test (OGTT)-based crossover randomized control study, the effect of a single premeal almond load (20 g) given before OGTT was evaluated (n = 60, 30 each period). (2) The continuous glucose monitoring system (CGMS)-based study for 3 days including premeal almond load before three major meals was a free-living, open-labeled, crossover randomized control trial, where control and premeal almond load diets were compared for glycaemic control (n = 60, 30 in each period). The study was registered at clinicaltrials.gov (registration no. NCT04769726).
Results
In the OGTT-based study phase, the overall AUC for blood glucose, serum insulin, C-peptide, and plasma glucagon post-75 g oral glucose load was significantly lower for treatment vs. control diet (p < 0.001). Specifically, with the former diet, PPHG was significantly lower (18.05% in AUC on OGTT, 24.8% at 1-h, 28.9% at 2-h post OGTT, and 10.07% during CGMS). The CGMS data showed that premeal almond load significantly improved 24-glucose variability; SD of mean glucose concentration and mean of daily differences. Daily glycaemic control improved significantly as per the following: mean 24-h blood glucose concentration (M), time spent above 7.8 mmol/L of blood glucose, together with the corresponding AUC values. Premeal almond load significantly decreased following: overall hyperglycemia (glucose AUC), PPHG, peak 24-h glycaemia, and minimum glucose level during night.
Conclusion
Incorporation of 20 g of almonds, 30 min before each major meal led to a significant decrease in PPHG (as revealed in OGTT-based study phase) and also improved insulin, C-peptide, glucagon levels, and improved glucose variability and glycemic parameters on CGMS in participants with prediabetes.
Clinical trial registry
The study was registered at clinicaltrials.gov (registration no. NCT04769726).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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