Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial
Wang W, Jiang Y, Zhu Z, Zhang S, Xuan M, Tan X, Kong X, Zhong H, Bulloch G, Xiong R, Yuan Y, Chen Y, Zhang J, Zeng J, Morgan IG, He M
Ophthalmology and therapy · 57 citas
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- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Fundamental Research Funds of the State key Laboratory of Ophthalmology
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-15 · Ophthalmol Ther · vol. 12 · número 2 · págs. 1223–1237
- Editorial
- Adis, Springer Healthcare
- Citado
- 66 citas · más que el 99% de estudios similares · 10.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Palabras clave
- Medicine, Randomized controlled trial, Post-hoc analysis, Ophthalmology, Nuclear medicine, Surgery, Internal medicine
16 autores
- Wei Wang🇨🇳Sun Yat-sen University
- Yu Jiang🇨🇳Sun Yat-sen University
- Zhuoting Zhu🇨🇳🇦🇺Sun Yat-sen University; The University of Melbourne; Centre for Eye Research Australia
- Shiran Zhang🇨🇳Sun Yat-sen University
- Meng Xuan🇨🇳Sun Yat-sen University
- Xingping Tan🇨🇳Central South University; Xiangya Hospital Central South University
- Xiangbin Kong🇨🇳Foshan Second People's Hospital
- Hui Zhong🇨🇳Shenzhen Children's Hospital
- Gabriella Bulloch🇦🇺The University of Melbourne; Centre for Eye Research Australia
- Ruilin Xiong🇨🇳Sun Yat-sen University
- Yixiong Yuan🇨🇳Sun Yat-sen University
- Yanping Chen🇨🇳Sun Yat-sen University
- Jian Zhang🇨🇳Sun Yat-sen University
- Junwen Zeng🇨🇳Sun Yat-sen University
- Ian George Morgan🇦🇺Australian National University
- Mingguang He🇨🇳🇦🇺 · autor de correspondenciaSun Yat-sen University; The University of Melbourne; Centre for Eye Research Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed in a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy.
Methods
This is a post hoc analysis of a multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8-13 years allocated to RLRL treatment (intervention group) or a single vision spectacle (SVS, control group) were included. AL was measured using an IOL-master 500 at baseline, 1-, 3-, 6-, and 12-month follow-up visits. AL shortening was defined as AL reduction from baseline to follow-up visits at three cutoffs: > 0.05 mm, > 0.10 mm, and > 0.20 mm. Frequency of AL shortening at different cutoffs was calculated. Analysis was done with intent to treat (ITT).
Results
At 12-months follow up, frequency of AL shortening > 0.05 mm was 26/119 (21.85%) and 2/145 (1.38%) for the RLRL group versus the control group, respectively. The frequency was 18/119 (15.13%) versus 0/145 (0%) for AL shortening > 0.10 mm, and 7/119 (5.88%) versus 0/145 (0%), for AL shortening > 0.20 mm, respectively (p < 0.001). Mean AL shortening after 12 months (SD) was -0.156 (0.086) mm in the RLRL group and -0.06 mm in the control group. Age was significantly associated with AL shortening in the multivariable analysis. For the RLRL group that exhibited AL shortening (n = 56), choroidal thickness (ChT) thickening (0.056 mm) could only explain 28.3% of AL shortening (-0.20 mm).
Conclusion
Nearly a quarter of children had > 0.05 mm AL shortening following 12 months of RLRL therapy, whereas AL shortening rarely occurred among controls.
Trial registration
ClinicalTrials.gov (NCT04073238).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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