The efficacy of honey or olive oil on the severity of oral mucositis and pain compared to placebo (standard care) in children with leukemia receiving intensive chemotherapy: A randomized controlled trial (RCT)
Badr LK, El Asmar R, Hakim S, Saad R, Merhi R, Zahreddine A, Muwakkit S
Journal of pediatric nursing · 9 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-02-13 · J Pediatr Nurs · vol. 70 · págs. e48–e53
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Oral Health Pathology and Treatment · Chemotherapy-related skin toxicity
- Palabras clave
- oral mucositis, manuka honey, olive oil, pediatric leukemia, chemotherapy complications, oral pain, complementary therapy, low-cost interventions
- MeSH
- humans, leukemia, stomatitis, pain, honey, child, olive oil
7 autores
- Lina Kurdahi Badr🇱🇧 · autor de correspondenciaAmerican University of Beirut
- Rebecca El Asmar🇱🇧 · autor de correspondenciaAmerican University of Beirut Medical Center
- Sarah Hakim🇱🇧American University of Beirut Medical Center; American University of Beirut
- Rima Saad🇱🇧American University of Beirut
- Roni Merhi🇱🇧American University of Beirut Medical Center
- Ammar Zahreddine🇱🇧 · autor de correspondenciaAmerican University of Beirut Medical Center; American University of Beirut
- Samar A. Muwakkit🇱🇧 · autor de correspondenciaAmerican University of Beirut Medical Center; American University of Beirut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral mucositis (OM) is a significant complication occurring in approximately 40 to 80% of patients receiving chemotherapy regimens. Although a wide variety of agents have been tested to prevent OM or reduce its severity, none have provided conclusive evidence.
Objectives
To determine the efficacy of honey or olive oil on the severity and OM pain in children with leukemia and suffering from OM compared to placebo (standard care) and, to assess which of the two interventions is more beneficial.
Methods
A single blind randomized controlled study (RCT) was used to evaluate the effect of Manuka honey or olive oil, in the treatment of chemotherapy-related OM in 42 children with leukemia. The primary outcome was the severity of mucositis, using the World Health Organization (WHO) scale and the secondary outcome was the pain assessed using the Visual analogue scale (VAS).
Results
Children who received the honey had less severe OM (assessed on the (WHO) scale), p = 0.00 and less pain (assessed on the VAS scale), p = 0.00, compared to the control group. Children who received the olive oil had less pain than the control group, p = 0.00), although not lower than the honey group.
Conclusion
Manuka honey or olive oil can be used as alternative therapies by nurses to children with leukemia and suffering from OM, especially in low and middle-income countries where more expensive therapies may not be available or economical.
Practice implications
Pediatric nurses may recommend Manuka honey to treat OM in children with leukemia as it is safe and inexpensive compared to other treatment modalities.
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