Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Ghavami A, Ziaei R, Talebi S, Barghchi H, Nattagh-Eshtivani E, Moradi S, Rahbarinejad P, Mohammadi H, Ghasemi-Tehrani H, Marx W, Askari G
Advances in nutrition (Bethesda, Md.) · 50 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-01 · Adv Nutr · vol. 14 · número 3 · págs. 465–474
- Editorial
- Elsevier BV
- Citado
- 83 citas · más que el 99% de estudios similares · 5.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Food composition and properties · Lipoproteins and Cardiovascular Health · Microbial Metabolites in Food Biotechnology
- Palabras clave
- lipid profile, LDL cholesterol, total cholesterol, triglycerides, apolipoprotein B, dyslipidemia, cardiovascular risk, dose-response relationship, dietary fiber
- MeSH
- humans, lipids, dietary supplements, adult, dyslipidemias, cholesterol, ldl, randomized controlled trials as topic
11 autores
- Abed Ghavami🇮🇷Isfahan University of Medical Sciences
- Rahele Ziaei🇮🇷Isfahan University of Medical Sciences
- Sepide Talebi🇮🇷Tehran University of Medical Sciences
- Hanieh Barghchi🇮🇷Mashhad University of Medical Sciences
- Elyas Nattagh‐Eshtivani🇮🇷Gonabad University of Medical Sciences
- Sajjad Moradi🇮🇷Kermanshah University of Medical Sciences
- Pegah Rahbarinejad🇮🇷Mashhad University of Medical Sciences
- Hamed Mohammadi🇮🇷Tehran University of Medical Sciences
- Hatav Ghasemi Tehrani🇮🇷Isfahan University of Medical Sciences
- Wolfgang Marx🇦🇺Barwon Health; Deakin University
- Gholamreza Askari🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
To present a comprehensive synthesis of the effect of soluble fiber supplementation on blood lipid parameters in adults, a systematic search was undertaken in PubMed, Scopus, and ISI Web of Science of relevant articles published before November 2021. Randomized controlled trials (RCTs) evaluating the effects of soluble fibers on blood lipids in adults were included. We estimated the change in blood lipids for each 5 g/d increment in soluble fiber supplementation in each trial and then calculated the mean difference (MD) and 95% CI using a random-effects model. We estimated dose-dependent effects using a dose-response meta-analysis of differences in means. The risk of bias and certainty of the evidence was evaluated using the Cochrane risk of bias tool and the Grading Recommendations Assessment, Development, and Evaluation methodology, respectively. A total of 181 RCTs with 220 treatment arms (14,505 participants: 7348 cases and 7157 controls) were included. There was a significant reduction in LDL cholesterol (MD: -8.28 mg/dL, 95% CI: -11.38, -5.18), total cholesterol (TC) (MD: -10.82 mg/dL, 95% CI: -12.98, -8.67), TGs (MD: -5.55 mg/dL, 95% CI: -10.31, -0.79), and apolipoprotein B (Apo-B) (MD: -44.99 mg/L, 95% CI: -62.87, -27.12) after soluble fiber supplementation in the overall analysis. Each 5 g/d increase in soluble fiber supplementation had a significant reduction in TC (MD: -6.11 mg/dL, 95% CI: -7.61, -4.61) and LDL cholesterol (MD: -5.57 mg/dl, 95% CI: -7.44, -3.69). In a large meta-analysis of RCTs, results suggest that soluble fiber supplementation could contribute to the management of dyslipidemia and the reduction of cardiovascular disease risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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