Adequate dietary magnesium intake may protect females but not males older than 55 years from cognitive impairment
Gao X, Sun Y, Huang X, Zhou Y, Zhu H, Li Q, Ma Y
Nutritional neuroscience · 4 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- [Community Cohort Study on Specialized Nervous System Diseases ]
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-02-19 · Nutr Neurosci · vol. 27 · número 2 · págs. 184–195
- Editorial
- Taylor & Francis
- Citado
- 3 citas · más que el 54% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Trace Elements in Health
- Palabras clave
- Medicine, Logistic regression, Cognition, Cohort, Risk factor, Magnesium, Cognitive decline, Cohort study, Gerontology, Physiology, Internal medicine, Demography, Dementia, Disease, Psychiatry
- MeSH
- humans, magnesium, diet, cohort studies, cognition, aged, middle aged, female, male, cognitive dysfunction
7 autores
- Xian Gao🇨🇳Hebei Medical University; First Affiliated Hospital of Hebei Medical University
- Yan Sun🇨🇳Hebei Medical University
- Xin Huang🇨🇳Hebei Medical University; Handan College
- Yutian Zhou🇨🇳Hebei Medical University
- Huichen Zhu🇨🇳Hebei Medical University
- Qingxia Li🇨🇳Hebei Medical University
- Yuxia Ma🇨🇳 · autor de correspondenciaHebei Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium is an essential nutrient required to maintain brain health throughout life, and adequate magnesium intake is positively associated with cognitive performance in older adults. However, sex differences in magnesium metabolism have not been adequately assessed in humans.
Objectives
We investigated sex differences in the effect of dietary magnesium intake and the risk of different types of cognitive impairment in older Chinese adults.
Methods
We collected and assessed dietary data and cognitive function status in people aged 55 years and older in northern China who participated in the Community Cohort Study of Nervous System Diseases from 2018 to 2019 to explore the relationship between dietary magnesium intake and the risk of each type of mild cognitive impairment (MCI) in sex-specific cohorts of older adults.
Results
The study included 612 people: 260 (42.5%) men and 352 (57.5%) women. Logistic regression results showed that for the total sample and women's sample, high dietary magnesium intake reduced the risk of amnestic MCI (ORtotal = 0.300; ORwomen = 0.190) and multidomain amnestic MCI (ORtotal = 0.225; ORwomen = 0.145). The results of restricted cubic spline analysis showed that the risk of amnestic MCI (ptotal = 0.0193; pwomen = 0.0351) and multidomain amnestic MCI (ptotal = 0.0089; pwomen = 0.0096) in the total sample and women's sample gradually decreased with increasing dietary magnesium intake.
Conclusions
The results suggest that adequate magnesium intake may have a preventive effect against the risk of MCI in older women.
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