Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults
Nitescu M, Istratescu D, Preda CM, Manuc TE, Louis E, Manuc M, Stroie T, Catrinoiu M, Tieranu CG, Badea LE, Tugui L, Andrei A, Diculescu MM
Medicina (Kaunas, Lithuania) · 14 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-09 · Medicina (Kaunas) · vol. 59 · número 2 · pág. 329
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 17 citas · más que el 93% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Digestive system and related health · Inflammatory Bowel Disease · Gastrointestinal motility and disorders
- Palabras clave
- Food science, Inflammatory Bowel Diseases, Medicine, Chemistry, Gastroenterology, Internal medicine, Inflammatory bowel disease
- MeSH
- animals, colitis, ulcerative, inflammatory bowel diseases, crohn disease, disaccharides, meat
13 autores
- Maria Nițescu🇷🇴Carol Davila University of Medicine and Pharmacy; National Institute of Research and Development for Biological Sciences
- Doina Istrătescu🇷🇴 · autor de correspondenciaCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Carmen Monica Preda🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Teodora Ecaterina Manuc🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Edouard J. Louis🇧🇪University of Liège; Centre Hospitalier Universitaire de Liège
- Mircea Mănuc🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Tudor Gheorghe Stroie🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Mihai Catrinoiu🇷🇴Carol Davila University of Medicine and Pharmacy
- Cristian George Ţieranu🇷🇴Clinical Emergency Hospital Bucharest
- Larisa Badea🇷🇴Institutul Clinic Fundeni
- Letiţia Tugui🇷🇴Institutul Clinic Fundeni
- Adriana Corina ANDREI🇷🇴Institutul Clinic Fundeni
- Mihai Mircea Diculescu🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and Objectives: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been linked to a higher risk of developing IBD. The aim of this study was to establish an association between an anti-inflammatory exclusion diet and maintenance of remission in IBD. Also, we assessed the efficacy and safety of this diet compared to a non-dietary group and the possible therapeutic effect of this diet in the maintenance of IBD remission. Materials and Methods: A total of 160 patients with IBD were screened for inclusion, but 21 did not met the inclusion criteria. Thus, 139 patients were assigned to either an exclusion diet or a regular diet according to their choice. Results: Clinical remission after six months was maintained in the exclusion diet arm (100%). In the control arm, four patients had clinically active disease (one patient with UC and three with CD), and 90 patients maintained the clinical remission state (95.7%) (p-value = 0.157). Regarding biochemical markers, ESR at baseline was higher in the exclusion diet arm: 29 (5-62) versus in the control arm 16 (4-48) (p-value = 0.019), but six months after, the groups were similar (p-value = 0.440). Conclusions: Patients who followed an exclusion diet maintained clinical remission more frequently. However, the threshold for statistical significance was not achieved. There was also a trend of improvement in inflammation tests in the intervention group.
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