Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials
Luo B, Mohammad WT, Jalil AT, Saleh MM, Al-Taee MM, Alshahrani MY, Alshahrani MY, Mohammed NM, Heydani A
Complementary therapies in medicine · 8 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Deanship of Scientific Research, King Khalid University
- Subvenciones
- Deanship of Scientific Research, King Khalid University (RGP.02/122/43)
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-02-24 · Complement Ther Med · vol. 73 · pág. 102935
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 60% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Bee Products Chemical Analysis
- Palabras clave
- Meta-analysis, Medicine, Malondialdehyde, Publication bias, Oxidative stress, Randomized controlled trial, Web of science, Internal medicine, Antioxidant, MEDLINE, Systematic review, Traditional medicine, Biochemistry
- MeSH
- humans, antioxidants, oxidative stress, dietary supplements, biomarkers, prunus dulcis
8 autores
- Bingfeng Luo🇨🇳 · autor de correspondenciaFirst Hospital of Lanzhou University; Lanzhou University
- Walid Theib Mohammad🇯🇴Al-Hussein Bin Talal University
- Abduladheem Turki Jalil🇮🇶 · autor de correspondenciaAlsalam University College; Al-Mustaqbal University
- Marwan Mahmood Saleh🇮🇶University of Anbar; Iraqi University; Islamic University of Najaf
- Muataz Mohammed Al‐Taee🇮🇶Al-Nisour University College
- Mohammad Yahya Alshahrani🇸🇦King Khalid University
- Naseer Mihdi MohammedMazaya University College
- Ammar Heydani · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Several randomized controlled trials (RCTs) have shown that almonds can improve oxidative stress indices, but the results are controversial. Therefore, the goal of this research was to carry out a systematic review and meta-analysis of all RCTs that evaluated the effect of almonds on selected oxidative stress indices.
Methods
A systematic search was conducted up to April 2022 on PubMed, Scopus, Web of Science, and Google Scholar. We have selected the studies that investigated the effects of almonds on malondialdehyde (MDA), and oxidized low-density lipoprotein (Ox-LDL) levels in adults. Data were pooled by using the random-effects model. The risk of bias in individual studies was assessed using the Cochrane Collaboration risk of bias tool.
Results
Seven RCTs involving 424 participants were analyzed. The results indicated that almond intake led to a significant decrease in MDA levels (WMD: - 6.63 nmol/ml; 95 % CI: - 8.72 to - 4.54; P < 0.001). However, no significant effect was observed on Ox-LDL (Hedges' g: - 0.12; 95 % CI: - 0.34 to 0.10; P = 0.28). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias.
Conclusion
The present meta-analysis suggests that almond intake can improve MDA levels and might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults. There is a need for more studies with larger groups to better estimate this effect.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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