Financiado en parte por U.S. Highbush Blueberry Council
Daily blueberry consumption for 12 weeks improves endothelial function in postmenopausal women with above-normal blood pressure through reductions in oxidative stress: a randomized controlled trial
Woolf EK, Terwoord JD, Litwin NS, Vazquez AR, Lee SY, Ghanem N, Michell KA, Smith BT, Grabos LE, Ketelhut NB, Bachman NP, Smith ME, Le Sayec M, Rao S, Gentile CL, Weir TL, Rodriguez-Mateos A, Seals DR, Dinenno FA, Johnson SA
Food & function · 35 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Universidad u hospital
- Colorado State University
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institute of Food and Agriculture
- Universidad u hospital
- Anschutz Medical Campus, University of Colorado
- Subvenciones
- National Institute of Food and Agriculture (2020-67017-30833/Project Accession 1021875); National Institute of Food and Agriculture (2020-67017-30833); National Institute of Food and Agriculture (1021875); National Institute of Food and Agriculture (2020-67017-30833/project accession no. 1)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2023-01-01 · Food Funct · vol. 14 · número 6 · págs. 2621–2641
- Editorial
- Royal Society of Chemistry
- Citado
- 44 citas · más que el 96% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 100 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- endothelial function, oxidative stress, postmenopausal women, hypertension, flavonoids, microbial metabolites, arterial stiffness, blood pressure
- MeSH
- endothelium, vascular, humans, hypertension, ascorbic acid, phenols, powders, double-blind method, oxidative stress, postmenopause, blood pressure, female, biomarkers, blueberry plants
20 autores
- Emily K. Woolf🇺🇸Colorado State University
- Janée D. Terwoord🇺🇸Colorado State University
- Nicole S. Litwin🇺🇸Colorado State University
- Allegra R. Vazquez🇺🇸Colorado State University
- Sylvia Y. Lee🇺🇸Colorado State University
- Nancy Ghanem🇺🇸Colorado State University
- Kiri A. Michell🇺🇸Colorado State University
- Brayden T. Smith🇺🇸Colorado State University
- Lauren E. Grabos🇺🇸Colorado State University
- Nathaniel B. Ketelhut🇺🇸Colorado State University
- Nate P. Bachman🇺🇸Colorado State University
- M. Smith🇺🇸Colorado State University
- Mélanie Le Sayec🇬🇧King's College London
- Sangeeta Rao🇺🇸Colorado State University
- Christopher L. Gentile🇺🇸Colorado State University
- Tiffany L. Weir🇺🇸Colorado State University
- Ana Rodriguez‐Mateos🇬🇧King's College London
- Douglas R. Seals🇺🇸University of Colorado Boulder
- Frank A. Dinenno🇺🇸Colorado State University
- Sarah A. Johnson🇺🇸 · autor de correspondenciaColorado State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Estrogen-deficient postmenopausal women have oxidative stress-mediated suppression of endothelial function that is exacerbated by high blood pressure. Previous research suggests blueberries may improve endothelial function through reductions in oxidative stress, while also exerting other cardiovascular benefits. The objective of this study was to examine the efficacy of blueberries to improve endothelial function and blood pressure in postmenopausal women with above-normal blood pressure, and to identify potential mechanisms for improvements in endothelial function. A randomized, double-blind, placebo-controlled, parallel-arm clinical trial was performed, where postmenopausal women aged 45-65 years with elevated blood pressure or stage 1-hypertension (total n = 43, endothelial function n = 32) consumed 22 g day-1 of freeze-dried highbush blueberry powder or placebo powder for 12 weeks. Endothelial function was assessed at baseline and 12 weeks through ultrasound measurement of brachial artery flow-mediated dilation (FMD) normalized to shear rate area under the curve (FMD/SRAUC) before and after intravenous infusion of a supraphysiologic dose of ascorbic acid to evaluate whether FMD improvements were mediated by reduced oxidative stress. Hemodynamics, arterial stiffness, cardiometabolic blood biomarkers, and plasma (poly)phenol metabolites were assessed at baseline and 4, 8, and 12 weeks, and venous endothelial cell protein expression was assessed at baseline and 12 weeks. Absolute FMD/SRAUC was 96% higher following blueberry consumption compared to baseline (p p > 0.05), and changes from baseline to 12 weeks were greater in the blueberry group than placebo (+1.09 × 10-4 ± 4.12 × 10-5vs. +3.82 × 10-6 ± 1.59 × 10-5, p AUC response to ascorbic acid infusion was lower (p p > 0.05). The sum of plasma (poly)phenol metabolites increased at 4, 8, and 12 weeks in the blueberry group compared to baseline, and were higher than the placebo group (all p < 0.05). Increases in several plasma flavonoid and microbial metabolites were also noted. No major differences were found for blood pressure, arterial stiffness, blood biomarkers, or endothelial cell protein expression following blueberry consumption. These findings suggest daily consumption of freeze-dried blueberry powder for 12 weeks improves endothelial function through reduced oxidative stress in postmenopausal women with above-normal blood pressure. The clinical trial registry number is NCT03370991 (https://clinicaltrials.gov).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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