Association of Dietary Nitrate, Nitrite, and N-Nitroso Compounds Intake and Gastrointestinal Cancers: A Systematic Review and Meta-Analysis
Seyyedsalehi MS, Mohebbi E, Tourang F, Sasanfar B, Boffetta P, Zendehdel K
Toxics · 63 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-17 · Toxics · vol. 11 · número 2 · pág. 190
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 98 citas · más que el 96% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 84 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Water Treatment and Disinfection · Nutritional Studies and Diet · Esophageal Cancer Research and Treatment
- Palabras clave
- Meta-analysis, Medicine, Nitrite, Relative risk, Carcinogen, Nitrate, Population, Internal medicine, Colorectal cancer, Cancer, Gastroenterology, Environmental health, Chemistry, Confidence interval, Biochemistry
6 autores
- Monireh Sadat Seyyedsalehi🇮🇷🇮🇹Tehran University of Medical Sciences; University of Bologna
- Elham Mohebbi🇺🇸🇮🇷Georgetown University; Georgetown University Medical Center; Tehran University of Medical Sciences
- Fatemeh Tourang🇮🇷Tehran University of Medical Sciences
- Bahareh Sasanfar🇮🇷Tehran University of Medical Sciences
- Paolo Boffetta🇺🇸🇮🇹Stony Brook University; University of Bologna
- Kazem Zendehdel🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
N-nitroso compounds (NOCs) are a class of chemical carcinogens found in various environmental sources such as food, drinking water, cigarette smoke, the work environment, and the indoor air population. We conducted a systematic review and meta-analysis to investigate the links between nitrate, nitrite, and NOCs in food and water and the risk of gastrointestinal (GI) cancers, including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), and pancreatic cancer (PC). A systematic search of the literature in Scopus, PubMed, Google Scholar, Web of Science, ScienceDirect, and Embase was performed for studies on the association between NOCs in drinking water and food sources and GI cancers. Forest plots of relative risk (RR) were constructed for all the cancer sites and the intake sources. The random-effects model was used to assess the heterogeneity between studies. Forty articles were included after removing duplicate and irrelevant articles. The meta-analysis indicated that the intake of high dose vs. low dose of these compounds was significantly associated with the overall GI cancer risk and nitrite (RR = 1.18, 95% CI = 1.07-1.29), and N-nitrosodimethylamine (NDMA) (RR = 1.32, 95% CI = 1.06-1.65). We found that dietary nitrite intake increased GC (RR = 1.33, 95% CI = 1.02-1.73), and EC (RR = 1.38, 95% CI = 1.01-1.89). Additionally, dietary NDMA intake increased the risk of CRC (RR = 1.36, 95% CI = 1.18-1.58). This meta-analysis provides some evidence that the intake of dietary and water nitrate, nitrite, and NOCs may be associated with GI cancers. In particular, dietary nitrite is linked to GC and EC risks and dietary NDMA intake is associated with CRC.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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