Dose-response meta-analysis of ultra-processed food with the risk of cardiovascular events and all-cause mortality: evidence from prospective cohort studies
Yuan L, Hu H, Li T, Zhang J, Feng Y, Yang X, Li Y, Wu Y, Li X, Huang H, Hu F, Chen C, Zhang M, Zhao Y, Hu D
Food & function · 36 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Guangdong Province
- Subvenciones
- National Natural Science Foundation of China (82273707); National Natural Science Foundation of China (81973152); National Natural Science Foundation of China (82073646); Natural Science Foundation of Guangdong Province (2021A1515012503)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-01-01 · Food Funct · vol. 14 · número 6 · págs. 2586–2596
- Editorial
- Royal Society of Chemistry
- Citado
- 50 citas · más que el 94% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Global Public Health Policies and Epidemiology
- Palabras clave
- ultra-processed foods, cardiovascular events, all-cause mortality, dose-response relationship, dietary intake, prospective cohort
- MeSH
- humans, cardiovascular diseases, diet, risk factors, prospective studies, cross-sectional studies, adult, food, processed
15 autores
- Lijun Yuan🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Huifang Hu🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Tian-Ze Li🇨🇳Shenzhen University
- Jinli Zhang🇨🇳Shenzhen University
- Yifei Feng🇨🇳Zhengzhou University
- Xingjin Yang🇨🇳Zhengzhou University
- Yang Li🇨🇳Shenzhen University
- Yuying Wu🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Xi Li🇨🇳Zhengzhou University
- Hao Huang🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Fulan Hu🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Chuanqi Chen
- Ming Zhang🇨🇳Shenzhen University; Shenzhen Luohu People's Hospital
- Yang Zhao🇨🇳Zhengzhou University
- Dongsheng Hu🇨🇳 · autor de correspondenciaShenzhen University; Shenzhen Luohu People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Previous meta-analyses included abundant cross-sectional studies, and/or only assessed high versus low categories of UPF consumption. We conducted this meta-analysis based on prospective cohort studies to estimate the dose-response associations of UPF consumption with the risk of cardiovascular events (CVEs) and all-cause mortality among general adults. Methods: PubMed, Embase, and Web of Science were searched for relevant articles published up to August 17, 2021, and newly published articles between August 17, 2021 and July 21, 2022 were re-searched. Random-effects models were used to estimate the summary relative risks (RRs) and confidence intervals (CIs). Generalized least squares regression was used to estimate the linear dose-response associations of each additional serving of UPF. Restricted cubic splines were used to model the possible nonlinear trends. Results: Eleven eligible papers (17 analyses) were finally identified. The pooled effect size for the highest versus lowest category of UPF consumption showed positive associations with the risk of CVEs (RR = 1.35, 95% CI, 1.18-1.54) and all-cause mortality (RR = 1.21, 95% CI, 1.15-1.27). For each additional daily serving of UPF, the risk increased by 4% (RR = 1.04, 95% CI, 1.02-1.06) for CVEs and 2% (RR = 1.02, 95% CI, 1.01-1.03) for all-cause mortality. With increasing UPF intake, the risk of CVEs reflected a linear upward trend (Pnonlinearity = 0.095), while all-cause mortality reflected a nonlinear upward trend (Pnonlinearity = 0.039). Conclusion: Our findings based on prospective cohorts suggested that any increased level of UPF consumption was linked to higher CVEs and mortality risk. Thus, the recommendation is to control the intake of UPF in daily diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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