Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank
Chang K, Gunter MJ, Rauber F, Levy RB, Huybrechts I, Kliemann N, Millett C, Vamos EP
EClinicalMedicine · 143 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- World Health Organization
- Universidad u hospital
- Centre International de Recherche sur le Cancer
- Organización sin fines de lucro
- World Cancer Research Fund International
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Organización sin fines de lucro
- World Cancer Research Fund
- Subvenciones
- Cancer Research UK (29678); Fundação de Amparo à Pesquisa do Estado de São Paulo (16/14302-7); Cancer Research UK (C33493/A29678); Fundação de Amparo à Pesquisa do Estado de São Paulo (29239); World Cancer Research Fund (IIG_FULL_2020_033); Fundação de Amparo à Pesquisa do Estado de São Paulo (18/19820-1); World Cancer Research Fund International (IIG_FULL_2020_033)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-01-31 · EClinicalMedicine · vol. 56 · pág. 101840
- Editorial
- Elsevier BV
- Citado
- 194 citas · más que el 100% de estudios similares · 44.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Culinary Culture and Tourism · Nutrition, Genetics, and Disease
- Palabras clave
- Medicine, Biobank, Environmental health, Cancer, Consumption (sociology), Scale (ratio), Prospective cohort study, Gerontology, Internal medicine, Bioinformatics
8 autores
- Kiara Chang🇬🇧 · autor de correspondenciaImperial College London
- Marc James Gunter🇫🇷Centre international de recherche sur le cancer
- Fernanda Rauber🇧🇷Universidade de São Paulo
- Renata Bertazzi Levy🇧🇷Universidade de São Paulo
- Inge Huybrechts🇫🇷Centre international de recherche sur le cancer
- Nathalie Kliemann🇫🇷Centre international de recherche sur le cancer
- Christopher J. Millett🇬🇧🇵🇹Imperial College London; Universidade Nova de Lisboa
- Eszter Panna Vamos🇬🇧Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Global dietary patterns are increasingly dominated by relatively cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). However, prospective evidence is limited on cancer development and mortality in relation to UPF consumption. This study examines associations between UPF consumption and risk of cancer and associated mortality for 34 site-specific cancers in a large cohort of British adults.
Methods
This study included a prospective cohort of UK Biobank participants (aged 40-69 years) who completed 24-h dietary recalls between 2009 and 2012 (N = 197426, 54.6% women) and were followed up until Jan 31, 2021. Food items consumed were categorised according to their degree of food processing using the NOVA food classification system. Individuals' UPF consumption was expressed as a percentage of total food intake (g/day). Prospective associations were assessed using multivariable Cox proportional hazards models adjusted for baseline socio-demographic characteristics, smoking status, physical activity, body mass index, alcohol and total energy intake.
Findings
The mean UPF consumption was 22.9% (SD 13.3%) in the total diet. During a median follow-up time of 9.8 years, 15,921 individuals developed cancer and 4009 cancer-related deaths occurred. Every 10 percentage points increment in UPF consumption was associated with an increased incidence of overall (hazard ratio, 1.02; 95% CI, 1.01-1.04) and specifically ovarian (1.19; 1.08-1.30) cancer. Furthermore, every 10 percentage points increment in UPF consumption was associated with an increased risk of overall (1.06; 1.03-1.09), ovarian (1.30; 1.13-1.50), and breast (1.16; 1.02-1.32) cancer-related mortality.
Interpretation
Our UK-based cohort study suggests that higher UPF consumption may be linked to an increased burden and mortality for overall and certain site-specific cancers especially ovarian cancer in women.
Funding
The Cancer Research UK and World Cancer Research Fund.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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