Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury
Lubarska M, Hałasiński P, Hryhorowicz S, Mahadea DS, Łykowska-Szuber L, Eder P, Dobrowolska A, Krela-Kaźmierczak I
International journal of environmental research and public health · 27 citas
Cómo se estudió
- Diseño
- Reporte de caso (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-02-22 · Int J Environ Res Public Health · vol. 20 · número 5 · pág. 3921
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 45 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Complementary and Alternative Medicine Studies · Drug-Induced Hepatotoxicity and Protection
- Palabras clave
- Medicine, Liver injury, Jaundice, Aspartate transaminase, Alanine transaminase, Bilirubin, Cholestasis, Liver function tests, Alkaline phosphatase, Internal medicine, Gastroenterology, Toxic hepatitis, Transaminase, Urine, Cirrhosis, Urinalysis, Physiology, Hepatitis, Biology, Biochemistry, Enzyme
- MeSH
- liver, humans, liver diseases, jaundice, alanine transaminase, aspartate aminotransferases, plant extracts, male, chemical and drug induced liver injury, chemical and drug induced liver injury, chronic
8 autores
- Marta Lubarska🇵🇱Poznan University of Medical Sciences
- Przemysław Hałasiński🇵🇱Poznan University of Medical Sciences
- Szymon Hryhorowicz🇵🇱 · autor de correspondenciaInstitute of Human Genetics; Polish Academy of Sciences
- Dagmara Mahadea🇵🇱Poznan University of Medical Sciences
- Liliana Łykowska‐Szuber🇵🇱Poznan University of Medical Sciences
- Piotr Eder🇵🇱Poznan University of Medical Sciences
- Agnieszka Dobrowolska🇵🇱Poznan University of Medical Sciences
- Iwona Krela‐Kaźmierczak🇵🇱Poznan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
In recent years, cases of liver damage caused by ashwagandha herbal supplements have been reported from different parts of the world (Japan, Iceland, India, and the USA). Here, we describe the clinical phenotype of suspected ashwagandha-induced liver injury and the potential causative mechanism. The patient was admitted to the hospital because of jaundice. In the interview, it was reported that he had been taking ashwagandha for a year. Laboratory results showed an increase in total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), (gamma-glutamyl transpherase (GGT), alkaline phosphatase (ALP), total cholesterol, triglycerides, and ferritin. Based on clinical symptoms and additional tests, the patient was diagnosed with acute hepatitis and referred to a facility with a higher reference rate to exclude drug-induced liver injury. An R-value was assessed, indicative of hepatocellular injury. The result of the 24 h urine collection exceeded the upper limit of normal for copper excretion in urine twice. The clinical condition improved after intensive pharmacological treatment and four plasmapheresis treatments. This case is another showing the hepatotoxic potential of ashwagandha to cause cholestatic liver damage mixed with severe jaundice. In view of several documented cases of liver damage caused by ashwagandha and the unknown metabolic molecular mechanisms of substances contained in it, attention should be paid to patients reporting the use of these products in the past and presenting symptoms of liver damage.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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