Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease
Ikonomidis I, Katogiannis K, Chania C, Iakovis N, Tsoumani M, Christodoulou A, Brinia E, Pavlidis G, Thymis J, Tsilivarakis D, Kountouri A, Korakas E, Lambadiari V, Triposkiadis F, Skaltsounis L, Tseti I, Iliodromitis EK, Andreadou I
European journal of clinical investigation · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Olive Heart Operational Programme Competitiveness, Entrepreneurship and Innovation 2014-2020 (EPAnEK)
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-03-13 · Eur J Clin Invest · vol. 53 · número 7 · pág. e13983
- Editorial
- Wiley
- Citado
- 34 citas · más que el 97% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities
- Palabras clave
- hydroxytyrosol, olive oil, vascular function, endothelial function, flow-mediated dilation, coronary flow reserve, pulse wave velocity, left ventricular diastolic function, oxidative stress, malondialdehyde, oxidized LDL, PCSK9, C-reactive protein, triglycerides, atherosclerosis prevention
- MeSH
- humans, heart diseases, coronary disease, phenylethyl alcohol, prospective studies, pulse wave analysis, olive oil, proprotein convertase 9
18 autores
- Ignatios Ikonomidis🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; University General Hospital Attikon
- Konstantinos Katogiannis🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; University General Hospital Attikon
- Christina Chania🇬🇷National and Kapodistrian University of Athens
- Nikolaos Iakovis🇬🇷University Hospital of Larissa
- Maria E. Tsoumani🇬🇷National and Kapodistrian University of Athens
- Andriana Christodoulou🇬🇷National and Kapodistrian University of Athens
- E Brinia🇬🇷National and Kapodistrian University of Athens
- George Pavlidis🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- John Thymis🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Damianos Tsilivarakis🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Aikaterini Kountouri🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Emmanouil Korakas🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Vaia Lambadiari🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Filippos K. Triposkiadis🇬🇷University Hospital of Larissa
- Alexios‐Léandros Skaltsounis🇬🇷National and Kapodistrian University of Athens
- Ioulia K. Tseti
- Efstathios K. Iliodromitis🇬🇷National and Kapodistrian University of Athens; University General Hospital Attikon
- Ioanna Andreadou🇬🇷National and Kapodistrian University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Hydroxytyrosol reduces low-density lipoprotein oxidation, contributing to prevention of atherosclerosis progression.
Methods
In a prospective, crossover, double-blind, placebo-controlled trial, 30 chronic coronary artery syndrome (CCAS) patients were randomized to 4 capsules/day, containing 412.5 mg olive oil with 2.5 mg hydroxytyrosol (OOHT) each one or placebo for 1 month and then were crossed over to the alternate treatment (placebo or OOHT). We measured (a) perfused boundary region (PBR) of the sublingual arterial microvessels (increased PBR indicates reduced glycocalyx thickness), (b) flow-mediated dilation (FMD), (c) Coronary Flow Reserve (CFR) and markers of LV diastolic function by Doppler echocardiography, (d) pulse wave velocity (PWV), and (e) oxidative stress, inflammatory biomarkers and blood lipids at baseline and after treatment.
Results
Treatment with OOHT improved PBR, FMD, CFR and PWV compared to baseline (1.8 ± .3 vs. 1.7 ± .4 μm, p = .040, 3.7 ± 2.1 vs. 6.5% ± 2.3%, p < .001, 2.3 ± .4 vs. 2.5 ± .4, p = .030 and 11.1 ± 1.8 vs. 11.8 ± 2.3 m/s, p = .002) while there was no effect after placebo (p = NS). No effect of OOHT treatment was observed on blood pressure. There was a parallel improvement of E' of the mitral annulus and deceleration time of the E wave of mitral inflow after OOHT (p < .05) but not after placebo. Compared to baseline, treatment with OOHT reduced malondialdehyde, a marker of lipid peroxidation, oxidized LDL, triglycerides, PCSK9 and CRP blood levels (p < .05) in contrast to placebo.
Conclusions
Hydroxytyrosol-enriched olive oil may have beneficial effects on endothelial, arterial and LV diastolic function likely by reducing oxidative and inflammatory burden in CCAS, though further studies are needed to confirm this mechanism.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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