Magnesium Supplementation May Not Be Protective against Carboplatin-Induced Nephrotoxicity But May Be Beneficial for Children Suffering Malignancies: A Randomized Clinical Trial
Alizadeh Hadadhania M, Ghaffari K, Absalan A, Eghbali A, Rahimi Afzal R, Ghasemi A, Eghbali A
Advanced biomedical research · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Arak University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-01-01 · Adv Biomed Res · vol. 12 · número 1 · pág. 11
- Editorial
- Medknow
- Citado
- 3 citas · más que el 61% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Chemotherapy-induced organ toxicity mitigation · Magnesium in Health and Disease · Biomedical Research and Pathophysiology
- Palabras clave
- Medicine, Carboplatin, Creatinine, Blood urea nitrogen, Renal function, Placebo, Nephrotoxicity, Urology, Randomized controlled trial, Magnesium, Clinical trial, Internal medicine, Chemotherapy, Gastroenterology, Kidney, Cisplatin, Pathology
9 autores
- Marzie Alizadeh Hadadhania🇮🇷Arak University of Medical Sciences
- Kazem Ghaffari🇮🇷Imam Khomeini Hospital
- Abdorrahim Absalan🇮🇷Imam Khomeini Hospital
- Aygin Eghbali🇮🇷 · autor de correspondenciaIran University of Medical Sciences
- Aygin Eghbali🇮🇷Arak University of Medical Sciences; Iran University of Medical Sciences
- Roghayeh Rahimi Afzal🇮🇷Arak University of Medical Sciences; Semnan University of Medical Sciences
- Ali Ghasemi🇮🇷Iran University of Medical Sciences; Semnan University of Medical Sciences
- Aziz Eghbali🇮🇷 · autor de correspondenciaIran University of Medical Sciences
- Aziz Eghbali🇮🇷Iran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium oxide may be effective in renal insufficiency prevention after carboplatin therapy. We have evaluated magnesium oxide impression on the serum creatinine (Cr) and blood urea nitrogen (BUN) levels plus glomerular filtration rate (GFR) in cancerous children.
Materials and methods
A group of children with different cancers (n = 18) was treated with 250 mg/day magnesium oxide supplementation (MOS) and compared with a matched placebo-treated group (n = 18). After 2 weeks, carboplatin chemotherapy started. We compared serum Cr, BUN, and GFR values before and 3 and 7 days post intervention.
Results
Serum Cr and BUN were increased significantly 3 and 7 days after intervention in both the groups. Serum Cr and BUN were not statistically different between the MOS and placebo groups before the intervention and 3 or 7 days after carboplatin administration (P > 0.05). Three days after the intervention, the GFR reduced from 101.38 ± 14.67 to 90.11 ± 10.52 mL/min/1.73 m2 in the MOS group. Furthermore, in the placebo group, 3 days after the intervention, the GFR was reduced from 97.5 ± 9.71 to 92.33 ± 10.61 mL/min/1.73 m2. Further, in the MOS group, after 7 days of the intervention, the GFR was reduced to 84.11 ± 12.47 mL/min/1.73 m2. In the placebo group, after 7 days of the intervention, the GFR was diminished to 85.38 ± 10.66 mL/min/1.73 m2 (P = 0.371).
Conclusion
The current study suggests that magnesium supplementation does not prevent carboplatin-induced nephrotoxicity in children with malignancies. Anyway, we propose magnesium oxide supplementation for this group of pediatrics because magnesium is an essential element for cell and tissue growth, maintenance, and metabolism.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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