Photobiomodulation therapy for the prevention of acute radiation dermatitis: a systematic review and meta-analysis
Gobbo M, Rico V, Marta GN, Caini S, Ryan Wolf J, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 17 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Multinational Association of Supportive Care in Cancer
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-23 · Support Care Cancer · vol. 31 · número 4 · pág. 227
- Editorial
- Springer Science+Business Media
- Citado
- 32 citas · más que el 89% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Effects of Radiation Exposure · Chemotherapy-related skin toxicity
- Palabras clave
- low-level laser therapy, acute radiation dermatitis, radiotherapy toxicity, radiation dermatitis prevention, breast cancer, head and neck cancer, radiotherapy interruption, skin toxicity
- MeSH
- breast, skin, humans, head and neck neoplasms, radiodermatitis, low-level light therapy
11 autores
- Margherita Gobbo🇮🇹Ca' Foncello Hospital
- Victoria Rico🇨🇦McMaster University
- Gustavo Nader Marta🇧🇷Hospital Sírio-Libanês
- Saverio Caini
- Julie Ryan Wolf🇺🇸University of Rochester Medicine; University of Rochester
- Corina J. G. van den Hurk🇳🇱Netherlands Comprehensive Cancer Organisation
- Mara G. Beveridge🇺🇸University Hospitals of Cleveland
- Henry Lam🇨🇦Sunnybrook Health Science Centre; University of Toronto
- Pierluigi Bonomo🇮🇹Azienda Ospedaliero-Universitaria Careggi
- Edward Chow🇨🇦University of Toronto
- Tara Behroozian🇨🇦 · autor de correspondenciaMcMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Approximately 95% of patients undergoing radiotherapy (RT) experience radiation dermatitis (RD). Evidence has suggested that photobiomodulation therapy (PBMT) can stimulate skin renewal and minimize RD. The aim of the present paper was to investigate the efficacy of PBMT in RD prevention through a comprehensive literature review.
Methods
A literature search of Ovid MEDLINE, Embase, and Cochrane databases was conducted from 1980 to March 2021 to identify RCT on the use of PBMT for RD prevention. Forest plots were developed using RevMan software to quantitatively compare data between studies.
Results
Five papers were identified: four in breast and one in head and neck cancer patients. Patients receiving PBMT experienced less severe RD than the control groups after 40 Gray (Gy) of RT (grade 3 toxicity: Odds Ratio (OR): 0.57, 95% CI 0.14-2.22, p = 0.42) and at the end of RT (grade 0 + 1 vs. 2 + 3 toxicity: OR: 0.28, 95% CI 0.15-0.53, p < 0.0001). RT interruptions due to RD severity were more frequent in the control group (OR: 0.81, 95% CI 0.10-6.58, p = 0.85).
Conclusion
Preventive PBMT may be protective against the development of severe grades of RD and reduce the frequency of RT interruptions. Larger sample sizes and other cancer sites at-risk of RD should be evaluated in future studies to confirm the true efficacy of PBMT, also in preventing the onset of RD and to finalize a standardized protocol to optimize the technique. At present, starting PBMT when RT starts is recommendable, as well as performing 2 to 3 laser sessions weekly.
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