Moderate doses of dietary nitrate elicit greater effects on blood pressure and endothelial function than a high dose: A 13-week pilot study
Babateen AM, Shannon OM, O'Brien GM, Olgacer D, Koehl C, Fostier W, Mathers JC, Siervo M
Nutrition, metabolism, and cardiovascular diseases : NMCD · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Newcastle University
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (MR/P020941/1)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-03-02 · Nutr Metab Cardiovasc Dis · vol. 33 · número 6 · págs. 1263–1267
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 90% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 14 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology
- Palabras clave
- dietary nitrate, beetroot juice, blood pressure, endothelial function, dose-response relationship, microvascular blood flow, older adults, overweight and obesity, nitric oxide
- MeSH
- humans, obesity, nitrates, pilot projects, double-blind method, blood pressure, dietary supplements, adult, aged, overweight
8 autores
- Abrar M. Babateen🇸🇦🇬🇧Umm al-Qura University; Newcastle University
- Oliver Michael Shannon🇬🇧Newcastle University
- Gerard O’Brien🇬🇧Newcastle University
- Dilara Olgacher🇬🇧Newcastle University
- Christina Koehl🇬🇧Newcastle University
- William Fostier🇬🇧Newcastle University
- John Cummings Mathers🇬🇧Newcastle University
- Mario Siervo🇬🇧🇦🇺 · autor de correspondenciaUniversity of Nottingham; Curtin University; University of Newcastle Australia; Newcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Few studies have explored the prolonged effects of dietary nitrate on vascular health. This pilot study tested the effects of prolonged consumption (13 weeks) of a range of doses of dietary nitrate (NO3-), provided as beetroot juice (BJ), on blood pressure (BP) and endothelial function in overweight and obese older participants.
Methods and results
Sixty-two overweight or obese older participants (60-75 years) were randomized to the following interventions: (1) high NO3- (2) medium NO3-, (3) low NO3-, or (4) placebo. Resting clinic and home BP were measured pre- and post-intervention. Laser Doppler iontophoresis was used to quantify changes in endothelial-dependent and independent microvascular blood flow.
Results
This pilot study showed that medium and low doses of NO3- were more effective in lowering resting-clinic SBP (P = 0.04 and, P = 0.03, respectively) than was PL. The lower doses of NO3- also resulted in significant increases in microvascular perfusion (medium, P = 0.02; low, P = 0.002) relative to baseline values.
Conclusion
These findings indicate that supplementation with medium and low, but not high, doses of NO3- for 13 weeks had positive effects on BP and endothelial function in older overweight and obese adults. These findings require confirmation in larger studies.
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