Pharmacological potential of <i>Withania somnifera</i> (L.) Dunal and <i>Tinospora cordifolia</i> (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions
Rizvi ZA, Babele P, Madan U, Sadhu S, Tripathy MR, Goswami S, Mani S, Dikshit M, Awasthi A
Frontiers in immunology · 16 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Department of Biotechnology, Ministry of Science and Technology, India
- Organización sin fines de lucro
- India Diabetes Research Foundation
- Universidad u hospital
- Translational Health Science and Technology Institute
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- Science and Engineering Research Board
- Gobierno
- Biotechnology Industry Research Assistance Council
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Subvenciones
- National Institutes of Health (USA-WA1/2020)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-07 · Front Immunol · vol. 14 · pág. 1138215
- Editorial
- Frontiers Media
- Citado
- 24 citas · más que el 95% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- SARS-CoV-2 and COVID-19 Research · Phytochemicals and Medicinal Plants · COVID-19 Clinical Research Studies
- Palabras clave
- Withania somnifera, Immunology, Inflammation, Medicine, Tinospora cordifolia, In vivo, Coronavirus, Biology, Pharmacology, Traditional medicine, Coronavirus disease 2019 (COVID-19), Disease, Internal medicine, Pathology
- MeSH
- neutrophils, animals, mice, transgenic, humans, mice, tinospora, withania, inflammation, rna, viral, plant extracts, cell differentiation, models, theoretical, pandemics, covid-19, sars-cov-2
9 autores
- Zaigham Abbas Rizvi🇮🇳 · autor de correspondenciaTranslational Health Science and Technology Institute
- Prabhakar Babele🇮🇳Translational Health Science and Technology Institute
- Upasna Madan🇮🇳Translational Health Science and Technology Institute
- Srikanth Sadhu🇮🇳Translational Health Science and Technology Institute
- Manas Ranjan Tripathy🇮🇳Translational Health Science and Technology Institute
- Sandeep Goswami🇮🇳Translational Health Science and Technology Institute
- Shailendra Mani🇮🇳Translational Health Science and Technology Institute
- Madhu Dikshit🇮🇳 · autor de correspondenciaCentral Drug Research Institute; Translational Health Science and Technology Institute
- Amit Awasthi🇮🇳 · autor de correspondenciaTranslational Health Science and Technology Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cytokine release syndrome (CRS) due to severe acute respiratory coronavirus-2 (SARS-CoV-2) infection leads to life-threatening pneumonia which has been associated with coronavirus disease (COVID-19) pathologies. Centuries-old Asian traditional medicines such as Withania somnifera (L.) Dunal (WS) and Tinospora cordifolia (Willd.) Miers (TC) possess potent immunomodulatory effects and were used by the AYUSH ministry, in India during the COVID-19 pandemic. In the present study, we investigated WS and TC's anti-viral and immunomodulatory efficacy at the human equivalent doses using suitable in vitro and in vivo models. While both WS and TC showed immuno-modulatory potential, WS showed robust protection against loss in body weight, viral load, and pulmonary pathology in the hamster model of SARS-CoV2. In vitro pretreatment of mice and human neutrophils with WS and TC had no adverse effect on PMA, calcium ionophore, and TRLM-induced ROS generation, phagocytosis, bactericidal activity, and NETs formation. Interestingly, WS significantly suppressed the pro-inflammatory cytokines-induced Th1, Th2, and Th17 differentiation. We also used hACE2 transgenic mice to further investigate the efficacy of WS against acute SARS-CoV2 infection. Prophylactic treatment of WS in the hACE2 mice model showed significant protection against body weight loss, inflammation, and the lung viral load. The results obtained indicate that WS promoted the immunosuppressive environment in the hamster and hACE2 transgenic mice models and limited the worsening of the disease by reducing inflammation, suggesting that WS might be useful against other acute viral infections. The present study thus provides pre-clinical efficacy data to demonstrate a robust protective effect of WS against COVID-19 through its broader immunomodulatory activity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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