Financiado en parte por Almond Board of California
Premeal almond load decreases postprandial glycaemia, adiposity and reversed prediabetes to normoglycemia: A randomized controlled trial
Gulati S, Misra A, Tiwari R, Sharma M, Pandey RM, Upadhyay AD, Chandra Sati H
Clinical nutrition ESPEN · 14 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-12-29 · Clin Nutr ESPEN · vol. 54 · págs. 12–22
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Diabetes, Cardiovascular Risks, and Lipoproteins · Food composition and properties
- Palabras clave
- almond, prediabetes, type 2 diabetes prevention, postprandial hyperglycemia, insulin resistance, weight loss, waist circumference, Asian Indians, HbA1c, grip strength, dietary intervention
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, hyperglycemia, obesity, body weight, cholesterol, blood glucose, hand strength, adolescent, adult, middle aged, adiposity, young adult, prunus dulcis
7 autores
- Seema Gulati🇮🇳National Diabetes Obesity and Cholesterol Foundation; Diabetes Foundation
- Anoop Misra🇮🇳 · autor de correspondenciaNational Diabetes Obesity and Cholesterol Foundation; Diabetes Foundation; Fortis C-DOC Hospital
- Rajneesh Tiwari🇮🇳National Diabetes Obesity and Cholesterol Foundation
- Meenu Sharma🇮🇳National Diabetes Obesity and Cholesterol Foundation
- Ravindra Mohan Pandey🇮🇳All India Institute of Medical Sciences
- Ashish Datt Upadhyay🇮🇳All India Institute of Medical Sciences
- Hem Chandra Sati🇮🇳All India Institute of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Asian Indians show rapid conversion from prediabetes to type 2 diabetes (T2D). Novel dietary strategies are needed to arrest this progression, by targeting postprandial hyperglycaemia (PPHG).
Design
We conducted a free-living randomized controlled open-label parallel arm study to evaluate the effect of a premeal load of almonds (20 g) 30 min before major meals on anthropometric, glycaemic, and metabolic parameters over 3 months. Sixty-six participants with prediabetes in the age range of 18-60 yrs were recruited. The study was registered at clinicaltrials.gov (registration no. NCT04769726).
Results
Thirty participants in each arm completed the study. As per 'intention-to-treat' analysis, overall additional mean reductions were statistically significant for body weight, BMI, waist circumference (WC), subscapular and suprailiac skinfolds, and improved handgrip strength (Kg) (p < 0·001 for all) in the treatment arm vs. the control arm (after multiple adjustments). In the blood parameters, the additional mean reduction in the treatment arm vs. control arm was statistically significant for fasting and post-75 g oral glucose-load blood glucose, postprandial insulin, HOMA-IR, HbA1c, proinsulin, total cholesterol, and very low-density lipoprotein cholesterol (p < 0·001 for all). Most importantly, we observed a reversal to normoglycemic state (fasting blood glucose and 2 h post-OGTT glucose levels) in 23.3% (7 out of 30) of participants in the treatment arm which is comparable to that seen with Acarbose treatment (25%).
Conclusion
Incorporation of 20 g of almonds, 30 min before each major meal leads to significant improvement in body weight, WC, glycemia (particularly PPHG), and insulin resistance and shows potential for reversal of prediabetes to normal glucose regulation over 3 months.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.