Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial
Wood E, Hein S, Mesnage R, Fernandes F, Abhayaratne N, Xu Y, Zhang Z, Bell L, Williams C, Rodriguez-Mateos A
The American journal of clinical nutrition · 84 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- China Scholarship Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-03-25 · Am J Clin Nutr · vol. 117 · número 6 · págs. 1306–1319
- Editorial
- Elsevier BV
- Citado
- 122 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 67 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Barrier Structure and Function Studies · Cardiovascular Health and Disease Prevention · Neurological Disease Mechanisms and Treatments
- Palabras clave
- Placebo, Crossover study, Medicine, Blood pressure, Internal medicine, Pathology
- MeSH
- humans, fruit, phenols, phenol, anthocyanins, powders, double-blind method, cognition, memory, short-term, aged, blueberry plants
10 autores
- Eleanor Wood🇬🇧King's College London
- Sabine Hein🇬🇧King's College London; University of Reading
- Robin Mesnage🇬🇧🇩🇪King's College London; Buchinger Wilhelmi
- Filipe Fernandes🇬🇧🇵🇹King's College London; Instituto Politécnico de Lisboa; King's College Hospital NHS Foundation Trust
- Nimaya Abhayaratne🇬🇧King's College London
- Yifan Xu🇬🇧King's College London
- Zicheng Zhang🇬🇧King's College London
- Lynne Bell🇬🇧University of Reading
- Claire Michelle Williams🇬🇧 · autor de correspondenciaUniversity of Reading
- Ana Rodriguez‐Mateos🇬🇧 · autor de correspondenciaKing's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence suggests that the intake of blueberry (poly)phenols is associated with improvements in vascular function and cognitive performance. Whether these cognitive effects are linked to increases in cerebral and vascular blood flow or changes in the gut microbiota is currently unknown.
Methods
A double-blind, parallel randomized controlled trial was conducted in 61 healthy older individuals aged 65-80 y. Participants received either 26 g of freeze-dried wild blueberry (WBB) powder (302 mg anthocyanins) or a matched placebo (0 mg anthocyanins). Endothelial function measured by flow-mediated dilation (FMD), cognitive function, arterial stiffness, blood pressure (BP), cerebral blood flow (CBF), gut microbiome, and blood parameters were measured at baseline and 12 wk following daily consumption. Plasma and urinary (poly)phenol metabolites were analyzed using microelution solid-phase extraction coupled with liquid chromatography-mass spectrometry.
Results
A significant increase in FMD and reduction in 24 h ambulatory systolic BP were found in the WBB group compared with the placebo group (0.86%; 95% CI: 0.56, 1.17, P < 0.001; -3.59 mmHg; 95% CI: -6.95, -0.23, P = 0.037; respectively). Enhanced immediate recall on the auditory verbal learning task, alongside better accuracy on a task-switch task was also found following WBB treatment compared with placebo (P < 0.05). Total 24 h urinary (poly)phenol excretion increased significantly in the WBB group compared with placebo. No changes in the CBF or gut microbiota composition were found.
Conclusions
Daily intake of WBB powder, equivalent to 178 g fresh weight, improves vascular and cognitive function and decreases 24 h ambulatory systolic BP in healthy older individuals. This suggests that WBB (poly)phenols may reduce future CVD risk in an older population and may improve episodic memory processes and executive functioning in older adults at risk for cognitive decline. Clinical Trial Registration number in clinicaltrials.gov: NCT04084457.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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