Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank
Dong X, Zhuang Z, Zhao Y, Song Z, Xiao W, Wang W, Li Y, Huang N, Jia J, Liu Z, Qi L, Huang T
Journal of the American Heart Association · 18 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Peking University
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-28 · J Am Heart Assoc · vol. 12 · número 7 · pág. e027934
- Editorial
- Wiley
- Citado
- 22 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease
- Palabras clave
- Medicine, Biobank, Prospective cohort study, Cohort, Disease, Metabolome, Cohort study, Coronary heart disease, Coronary artery disease, Internal medicine, Environmental health, Bioinformatics
- MeSH
- humans, myocardial ischemia, diet, risk factors, cohort studies, prospective studies, meat, middle aged, biological specimen banks, female, male, genome-wide association study, metabolome, red meat, united kingdom
12 autores
- Xue Yuan Dong🇨🇳Peking University
- Zhenhuang Zhuang🇨🇳Peking University
- Yimin Zhao🇨🇳Peking University
- Zimin Song🇨🇳Peking University
- Wendi Xiao🇨🇳Peking University
- Wenxiu Wang🇨🇳Peking University
- Yueying Li🇨🇳Peking University
- Ninghao Huang🇨🇳Peking University
- Jinzhu Jia🇨🇳Peking University
- Zhonghua Liu🇺🇸Columbia University
- Lu Qi🇺🇸Tulane University; Harvard University
- Tao Huang🇨🇳Peking University; Beijing Academy of Artificial Intelligence
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background The evidence is equivocal on the association between meat consumption and ischemic heart disease (IHD) risk. To what extent the variation of individuals' metabolic responses to the same diet may account for this association is not fully understood. We aim to identify metabolomic signatures characterizing consumption of unprocessed red meat and processed meat and whether such signatures are associated with IHD risk. Methods and Results We conducted a cohort study of 92 246 individuals (mean age, 56.1 years; 55.1% women) using the UK Biobank. During the median follow-up of 8.74 years, 3059 incident IHD events were documented. Unprocessed red meat and processed meat consumption was assessed using a touchscreen dietary questionnaire. Plasma metabolome was profiled by high-throughput nuclear magnetic resonance spectroscopy. Cox proportional hazards regression model was used to test the association of meat consumption with IHD. Genome-wide association analysis and 1-sample Mendelian randomization were performed for metabolomic signatures and causal association of signatures with IHD. Using elastic net regularized regressions, we constructed metabolomic signatures consisting of 157 and 142 metabolites for unprocessed red meat (Spearman correlation coefficient [r]=0.223) and processed meat (r=0.329), respectively. These signatures showed positive associations with incident IHD (red meat related signature: hazard ratio [HR] per SD increment=1.11 [95% CI, 1.06-1.16], PP<0.001). Genome-wide association studies identified 45 and 4 loci, involved in lipid and lipoprotein metabolism, for red and processed meat related signatures. Mendelian randomization showed that there were casual associations of signatures with risk of incident IHD. Conclusions We identify metabolomic signatures that reflect consumption of unprocessed red meat and processed meat, and these signatures are associated with an increased risk of IHD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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