The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry
Zhao F, Wang J, Wang W, Lyu L, Wu W, Li W
Molecules (Basel, Switzerland) · 16 citas
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Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Jiangsu Agriculture Research System
- Gobierno
- the 'JBGS' Project of Seed Industry Revitalization in Jiangsu Province
- Gobierno
- the Jiangsu Province Key Project of R&D Plan (Modern Agriculture)
- Gobierno
- Jiangsu Province Key Project of R&D Plan (Modern Agriculture)
- Gobierno
- Jiangsu Agricultural Industry Technology System
- Subvenciones
- Jiangsu Agriculture Research System (JATS [2022]510); Jiangsu Agriculture Research System (BE2020344)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-22 · Molecules · vol. 28 · número 6 · pág. 2850
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 33 citas · más que el 93% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Ginkgo biloba and Cashew Applications · Pomegranate: compositions and health benefits
- Palabras clave
- Anthocyanin, Apoptosis, Chemistry, HeLa, In vivo, Cancer cell, In vitro, Cell growth, Cisplatin, MTT assay, IC50, Biochemistry, Pharmacology, Cancer, Food science, Biology, Chemotherapy, Biotechnology
- MeSH
- humans, fruit, flavonoids, anthocyanins, plant extracts, antioxidants, cell proliferation, blueberry plants
6 autores
- Fengyi Zhao🇨🇳Institute of Botany; Institute of Botany, Jiangsu Province and Chinese Academy of Sciences; Jiangsu Provincial Key Laboratory for the Research and Utilization of Plant Resources
- Jialuan Wang🇨🇳Institute of Botany; Institute of Botany, Jiangsu Province and Chinese Academy of Sciences; Jiangsu Provincial Key Laboratory for the Research and Utilization of Plant Resources
- Weifan Wang🇨🇳Nanjing Forestry University
- Lianfei Lyu🇨🇳Institute of Botany; Institute of Botany, Jiangsu Province and Chinese Academy of Sciences; Jiangsu Provincial Key Laboratory for the Research and Utilization of Plant Resources
- Wenlong Wu🇨🇳 · autor de correspondenciaInstitute of Botany; Institute of Botany, Jiangsu Province and Chinese Academy of Sciences; Jiangsu Provincial Key Laboratory for the Research and Utilization of Plant Resources
- Weilin Li🇨🇳 · autor de correspondenciaNanjing Forestry University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries are rich in flavonoids, anthocyanins, phenolic acids, and other bioactive substances. Anthocyanins are important functional components in blueberries. We collected 65 varieties of blueberries to investigate their nutritional and functional values. Among them, Gardenblue had the highest anthocyanin content, with 2.59 mg/g in fresh fruit. After ultrasound-assisted solvent extraction and macroporous resin absorption, the content was increased to 459.81 mg/g in the dried powder. Biological experiments showed that Gardenblue anthocyanins (L1) had antiproliferative effect on cervical cancer cells (Hela, 51.98 μg/mL), liver cancer cells (HepG2, 23.57 μg/mL), breast cancer cells (MCF-7, 113.39 μg/mL), and lung cancer cells (A549, 76.10 μg/mL), and no apparent toxic effects were indicated by methyl thiazolyl tetrazolium (MTT) assay, especially against HepG2 cells both in vitro and in vivo. After combining it with DDP (cisplatin) and DOX (doxorubicin), the antiproliferative effects were enhanced, especially when combined with DOX against HepG2 cells; the IC50 value was 0.02 μg/mL. This was further evidence that L1 could inhibit cell proliferation by inducing apoptosis. The detailed mechanism might be L1 interacting with DNA in an intercalation mode that changes or destroys DNA, causing apoptosis and inhibiting cell proliferation. The findings of this study suggest that L1 extract can be used as a functional agent against hepatoma carcinoma cells.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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