Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis
Monteiro EB, Ajackson M, Stockler-Pinto MB, Guebre-Egziabher F, Daleprane JB, Soulage CO
Life sciences · 17 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-04-05 · Life Sci · vol. 322 · pág. 121664
- Editorial
- Elsevier BV
- Citado
- 24 citas · más que el 67% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Advanced Glycation End Products research · Sulfur Compounds in Biology
- Palabras clave
- Renal function, Medicine, Creatinine, Urology, Kidney disease, Sulforaphane, Kidney, Internal medicine, Acute kidney injury, Proteinuria, Glomerulosclerosis, Gastroenterology, Endocrinology, Pathology
- MeSH
- humans, kidney diseases, isothiocyanates, sulfoxides, creatinine, nf-e2-related factor 2, biomarkers, kelch-like ech-associated protein 1
6 autores
- Elisa Bernardes Monteiro🇧🇷Universidade do Estado do Rio de Janeiro
- Matheus Ajackson🇧🇷Universidade do Estado do Rio de Janeiro
- Milena Barcza Stockler‐Pinto🇧🇷Universidade Federal Fluminense
- Fitsum Guebre‐Egziabher🇫🇷Lyon 1 Université; Inserm; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Hospices Civils de Lyon; Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition
- Júlio Beltrame Daleprane🇧🇷Universidade do Estado do Rio de Janeiro
- Christophe Olivier Soulage🇫🇷 · autor de correspondenciaLyon 1 Université; Inserm; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, has received extensive attention as a natural activator of the Nrf2/Keap1 cytoprotective pathway. In this review, a meta-analysis and systematic review of the renoprotective effects of SFN were performed in various preclinical models of kidney diseases.
Main methods
The primary outcome was the impact of SFN on renal function biomarkers (uremia, creatininemia, proteinuria or creatinine clearance) and secondary outcomes were kidney lesion histological indices/kidney injury molecular biomarkers. The effects of SFN were evaluated according to the standardized mean differences (SMDs). A random-effects model was applied to estimate the overall summary effect.
Key findings
Twenty-five articles (out of 209 studies) were selected from the literature. SFN administration significantly increased creatinine clearance (SMD +1.88 95 % CI: [1.09; 2.68], P 2 = 0 %) and decreased the plasma creatinine (SMD -1.24, [-1.59; -0.88], P 2 = 36.0 %) and urea (SMD -3.22 [-4.42, -2.01], P 2 = 72.4 %) levels. SFN administration (median dose: 2.5 mg/kg, median duration: 3 weeks) significantly decreased urinary protein excretion (SMD -2.20 [-2.68; -1.73], P 2 = 34.1 %). It further improved two kidney lesion histological indices namely kidney fibrosis (SMD -3.08 [-4.53; -1.63], P 2 = 73.7 %) and glomerulosclerosis (SMD -2.24 [-2.96; -1.53], P 2 = 9.7 %) and decreased kidney injury molecular biomarkers (SMD -1.51 [-2.00; -1.02], P 2 = 0 %).
Significance
These findings provide new insights concerning preclinical strategies for treating kidney disease or kidney failure with SFN supplements and should stimulate interest in clinical evaluations of SFN in patients with kidney disease.
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