Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial
Teong XT, Liu K, Vincent AD, Bensalem J, Liu B, Hattersley KJ, Zhao L, Feinle-Bisset C, Sargeant TJ, Wittert GA, Hutchison AT, Heilbronn LK
Nature medicine · 106 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Australian Government
- Organización sin fines de lucro
- Diabetes Australia
- Universidad u hospital
- University of Adelaide
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Gobierno
- Department of Health | National Health and Medical Research Council
- Subvenciones
- Diabetes Australia (Y21G-SART); National Health and Medical Research Council (1143092)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2023-04-01 · Nat Med · vol. 29 · número 4 · págs. 963–972
- Editorial
- Nature Portfolio
- Citado
- 135 citas · más que el 100% de estudios similares · 19.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Enhanced Recovery After Surgery
- Palabras clave
- intermittent fasting, time-restricted eating, caloric restriction, type 2 diabetes prevention, glucose tolerance, postprandial blood glucose, meal timing, fasting, weight loss
- MeSH
- humans, diabetes mellitus, type 2, glucose, caloric restriction, fasting, adult, intermittent fasting
12 autores
- Xiao Tong Teong🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Kai Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Andrew D. Vincent🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Julien Bensalem🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Kathryn J. Hattersley🇦🇺South Australian Health and Medical Research Institute
- Lijun Zhao🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Christine Feinle‐Bisset🇦🇺The University of Adelaide
- Timothy J. Sargeant🇦🇺South Australian Health and Medical Research Institute
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting appears an equivalent alternative to calorie restriction (CR) to improve health in humans. However, few trials have considered applying meal timing during the 'fasting' day, which may be a limitation. We developed a novel intermittent fasting plus early time-restricted eating (iTRE) approach. Adults (N = 209, 58 ± 10 years, 34.8 ± 4.7 kg m-2) at increased risk of developing type 2 diabetes were randomized to one of three groups (2:2:1): iTRE (30% energy requirements between 0800 and 1200 hours and followed by a 20-h fasting period on three nonconsecutive days per week, and ad libitum eating on other days); CR (70% of energy requirements daily, without time prescription); or standard care (weight loss booklet). This open-label, parallel group, three-arm randomized controlled trial provided nutritional support to participants in the iTRE and CR arms for 6 months, with an additional 12-month follow-up. The primary outcome was change in glucose area under the curve in response to a mixed-meal tolerance test at month 6 in iTRE versus CR. Glucose tolerance was improved to a greater extent in iTRE compared with CR (-10.10 (95% confidence interval -14.08, -6.11) versus -3.57 (95% confidence interval -7.72, 0.57) mg dl-1 min-1; P = 0.03) at month 6, but these differences were lost at month 18. Adverse events were transient and generally mild. Reports of fatigue were higher in iTRE versus CR and standard care, whereas reports of constipation and headache were higher in iTRE and CR versus standard care. In conclusion, incorporating advice for meal timing with prolonged fasting led to greater improvements in postprandial glucose metabolism in adults at increased risk of developing type 2 diabetes. ClinicalTrials.gov identifier NCT03689608 .
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