The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers
Wei BZ, Li L, Dong CW, Tan CC, Alzheimer’s Disease Neuroimaging Initiative, Xu W
The American journal of clinical nutrition · 119 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (U01-AG-024904); National Natural Science Foundation of China (82001136)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2023-04-05 · Am J Clin Nutr · vol. 117 · número 6 · págs. 1096–1109
- Editorial
- Elsevier BV
- Citado
- 167 citas · más que el 100% de estudios similares · 24.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 88 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- omega-3 fatty acids, dementia, cognitive decline, Alzheimer's disease, docosahexaenoic acid, eicosapentaenoic acid, omega-3 supplementation, dietary intake, blood biomarkers, APOE ε4, dose-response relationship, ADNI cohort, meta-regression, prospective cohort, risk mitigation
- MeSH
- humans, alzheimer disease, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, cohort studies, prospective studies, eating, dietary supplements, aged, cognitive dysfunction
5 autores
- Bao‐Zhen Wei🇨🇳Qingdao University; Affiliated Hospital of Qingdao University; Qingdao Municipal Hospital
- Lin Li🇨🇳Qingdao University; Linyi People's Hospital
- Cheng‐Wen Dong🇨🇳Affiliated Hospital of Qingdao University
- Chen‐Chen Tan🇨🇳Qingdao University; Qingdao Municipal Hospital
- Wei Xu🇨🇳 · autor de correspondenciaQingdao University; Qingdao Municipal Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous data have linked omega-3 fatty acids with risk of dementia. We aimed to assess the longitudinal relationships of omega-3 polyunsaturated fatty acid intake as well as blood biomarkers with risk of Alzheimer's disease (AD), dementia, or cognitive decline. Longitudinal data were derived from 1135 participants without dementia (mean age = 73 y) in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort to evaluate the associations of omega-3 fatty acid supplementation and blood biomarkers with incident AD during the 6-y follow-up. A meta-analysis of published cohort studies was further conducted to test the longitudinal relationships of dietary intake of omega-3 and its peripheral markers with all-cause dementia or cognitive decline. Causal dose-response analyses were conducted using the robust error meta-regression model. In the ADNI cohort, long-term users of omega-3 fatty acid supplements exhibited a 64% reduced risk of AD (hazard ratio: 0.36, 95% confidence interval: 0.18, 0.72; P = 0.004). After incorporating 48 longitudinal studies involving 103,651 participants, a moderate-to-high level of evidence suggested that dietary intake of omega-3 fatty acids could lower risk of all-cause dementia or cognitive decline by ∼20%, especially for docosahexaenoic acid (DHA) intake (relative risk [RR]: 0.82, I2 = 63.6%, P = 0.001) and for studies that were adjusted for apolipoprotein APOE ε4 status (RR: 0.83, I2 = 65%, P = 0.006). Each increment of 0.1 g/d of DHA or eicosapentaenoic acid (EPA) intake was associated with an 8% ∼ 9.9% (Plinear 2 = 38.1%) and erythrocyte membrane DHA (RR: 0.94, I2 = 0.4%) were associated with a lower risk of cognitive decline. Dietary intake or long-term supplementation of omega-3 fatty acids may help reduce risk of AD or cognitive decline.
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