Genetics of caffeine and brain-related outcomes - a systematic review of observational studies and randomized trials
Kapellou A, King A, Graham CAM, Pilic L, Mavrommatis Y
Nutrition reviews · 27 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-04-08 · Nutr Rev · vol. 81 · número 12 · págs. 1571–1598
- Editorial
- Oxford University Press
- Citado
- 36 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Pharmacogenetics and Drug Metabolism · Nutrition, Genetics, and Disease
- Palabras clave
- caffeine, caffeine metabolism, CYP1A2, adenosine A2A receptor, genetic polymorphism, caffeine sensitivity, cognitive performance, anxiety, insomnia, sleep disorders, caffeine supplementation, gene-diet interaction
- MeSH
- brain, humans, sleep initiation and maintenance disorders, caffeine, cytochrome p-450 cyp1a2, adult, randomized controlled trials as topic, genome-wide association study
5 autores
- Angeliki Kapellou🇬🇧 · autor de correspondenciaSt Mary's University Twickenham London
- Alexandra King🇬🇧St Mary's University Twickenham London
- Catherine Graham🇨🇭Cereneo
- Leta Pilić🇬🇧St Mary's University Twickenham London
- Yiannis Mavrommatis🇬🇧St Mary's University Twickenham London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Although the stimulant and anxiogenic properties of caffeine are widely accepted, research on its specific effects on the brain remains controversial. Growing evidence shows that interindividual differences in caffeine response may be partly due to variations in genes such as CYP1A2 and ADORA2A, which have been used to identify individuals as "fast" or "slow" caffeine metabolizers and as having a "high" or "low" caffeine sensitivity, respectively.
Objective
The objective of this review was to identify, evaluate, and discuss current evidence on the associations between common genetic variants, caffeine consumption, and brain-related outcomes in humans.
Data sources
PubMed and Embase databases were searched for relevant reports based on a predetermined search strategy.
Data extraction
Reports of observational and experimental studies on healthy adults who underwent (a) genetic analysis for polymorphisms in genes associated with caffeine metabolism and effects and (b) measurements of brain-related effects such as anxiety, insomnia, and cognitive performance associated with the consumption of caffeine (habitual intake or supplementation) were included.
Data analysis
Of the 22 records included, 15 were randomized controlled trials, 6 were cross-sectional studies, and 1 was a genome-wide association study. The main outcomes identified were cognitive performance (n = 9), anxiety (n = 7), and sleep disturbance/insomnia (n = 6). Polymorphisms in the CYP1A2 gene were associated with cognitive function, while variations in the ADORA2A gene were associated with anxiety and sleep disturbance.
Conclusion
The present review has provided evidence that variability in the CYP1A2 and the ADORA2A genes may modulate the association between caffeine and brain-related outcomes. Future studies are warranted to investigate the specific polymorphisms implicated in each brain outcome, which cognitive functions are particularly related to caffeine (simple vs complex), whether there are gender differences in anxiety effects, and how habitual caffeine intake may influence the acute effects of caffeine.
Systematic review registration
PROSPERO registration no. CRD42021257556.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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