Efficacy of Repeated Low-Level Red-Light Therapy for Slowing the Progression of Childhood Myopia: A Systematic Review and Meta-analysis
Tang J, Liao Y, Yan N, Dereje SB, Wang J, Luo Y, Wang Y, Zhou W, Wang X, Wang W
American journal of ophthalmology · 62 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-04-07 · Am J Ophthalmol · vol. 252 · págs. 153–163
- Editorial
- Elsevier BV
- Citado
- 84 citas · más que el 97% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Laser Applications in Dentistry and Medicine · Ocular and Laser Science Research
- Palabras clave
- low-level red light therapy, childhood myopia, myopia progression, spherical equivalent refractive error, axial elongation, low-level laser therapy, children and adolescents
- MeSH
- choroid, humans, myopia, phototherapy, adolescent, child
10 autores
- Jie Ting Tang🇨🇳Xuzhou Medical College
- Ya Long Liao
- Na Yan🇨🇳Xuzhou Medical College
- Blen Dereje Shiferaw🇨🇳Xuzhou Medical College
- Jingjing Wang🇨🇳Xuzhou Medical College
- Yunjiao Luo🇨🇳Xuzhou Medical College
- Yuhao Wang🇨🇳Xuzhou Medical College
- Wen Zhou
- Xiaojuan Wang · autor de correspondencia
- Wei Wang🇨🇳 · autor de correspondenciaXuzhou Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To evaluate the long-term efficacy and safety of repeated low-intensity red light (RLRL) treatment for childhood myopia.
Design
Systematic review and meta-analysis METHODS: We searched PubMed, Web of Science, CNKI, and Wanfang from inception to February 8, 2023. We used the RoB 2.0 and ROBINS-I tools to assess the risk of bias and then used a random-effect model to calculate the weighted mean difference (WMD) and 95% CIs. The primary outcomes were WMD in spherical equivalent refractive error (SER), WMD in axial length (AL), and WMD in subfoveal choroid thickness (SFChT). Subgroup analyses were performed to investigate the sources of heterogeneity based on variation in follow-up and study design. The Egger and Begg tests were used to assess publication bias. Sensitivity analysis was used to verify the stability.
Results
This analysis included 13 studies (8 randomized controlled trials, 3 non-randomized controlled trials, and 2 cohort studies) involving 1857 children and adolescents. Eight studies met the meta-analysis criteria, and the WMD for myopia progression between RLRL and the control group was 0.68 diopters (D) per 6 months (95% CI = 0.38 to 0.97 D; I2 = 97.7%; P 2 = 98.0%; P 2 = 89.6%; P < .001) for SFChT change.
Conclusions
Our meta-analysis shows that RLRL therapy may be effective for delaying the progression of myopia. The evidence is low certainty, and larger and better randomized clinical trials with 2-year follow-ups are needed to improve the existing state of knowledge to inform medical guidelines more comprehensively.
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