A systematic review and meta-analysis of cold exposure and cardiovascular disease outcomes
Fan JF, Xiao YC, Feng YF, Niu LY, Tan X, Sun JC, Leng YQ, Li WY, Wang WZ, Wang YK
Frontiers in cardiovascular medicine · 73 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- U.S. Naval Academy
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-27 · Front Cardiovasc Med · vol. 10 · pág. 1084611
- Editorial
- Frontiers Media
- Citado
- 111 citas · más que el 97% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Climate Change and Health Impacts · Thermal Regulation in Medicine · Adipose Tissue and Metabolism
- Palabras clave
- Medicine, Relative risk, Disease, Meta-analysis, Internal medicine, Extreme Cold, Population, Coronary artery disease, Confidence interval, Cardiology, Environmental health
10 autores
- Jie‐Fu Fan🇨🇳Second Military Medical University
- Yuchen Xiao🇨🇳Second Military Medical University
- Yifei Feng🇨🇳Second Military Medical University
- Lu-Yu Niu🇨🇳Second Military Medical University
- Xing Lin Tan🇨🇳Second Military Medical University
- Jia‐Cen Sun🇨🇳Second Military Medical University
- Yue-Qi Leng🇨🇳Second Military Medical University
- Wan-Yang Li🇨🇳Second Military Medical University
- Weizhong Wang🇨🇳Second Military Medical University
- Yang‐Kai Wang🇨🇳Second Military Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cold exposure has been considered an essential risk factor for the global disease burden, while its role in cardiovascular diseases is still underappreciated. The increase in frequency and duration of extreme cold weather events like cold spells makes it an urgent task to evaluate the effects of ambient cold on different types of cardiovascular disease and to understand the factors contributing to the population's vulnerability.
Methods
In the present systematic review and meta-analysis, we searched PubMed, Scopus, and Cochrane. We included original research that explored the association between cold exposure (low temperature and cold spell) and cardiovascular disease outcomes (mortality and morbidity). We did a random-effects meta-analysis to pool the relative risk (RR) of the association between a 1°C decrease in temperature or cold spells and cardiovascular disease outcomes.
Results
In total, we included 159 studies in the meta-analysis. As a result, every 1°C decrease in temperature increased cardiovascular disease-related mortality by 1.6% (RR 1.016; [95% CI 1.015-1.018]) and morbidity by 1.2% (RR 1.012; [95% CI 1.010-1.014]). The most pronounced effects of low temperatures were observed in the mortality of coronary heart disease (RR 1.015; [95% CI 1.011-1.019]) and the morbidity of aortic aneurysm and dissection (RR 1.026; [95% CI 1.021-1.031]), while the effects were not significant in hypertensive disease outcomes. Notably, we identified climate zone, country income level and age as crucial influential factors in the impact of ambient cold exposure on cardiovascular disease. Moreover, the impact of cold spells on cardiovascular disease outcomes is significant, which increased mortality by 32.4% (RR 1.324; [95% CI 1.2341.421]) and morbidity by 13.8% (RR 1.138; [95% CI 1.015-1.276]).
Conclusion
Cold exposure could be a critical risk factor for cardiovascular diseases, and the cold effect varies between disease types and climate zones.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO, identifier: CRD42022347247.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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