Exploration of Metabolic Biomarkers Linking Red Meat Consumption to Ischemic Heart Disease Mortality in the UK Biobank
Fan B, Huang X, Zhao JV
Nutrients · 9 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Hong Kong Start Up Fund
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-04-13 · Nutrients · vol. 15 · número 8 · pág. 1865
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 11 citas · más que el 73% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Meat and Animal Product Quality
- Palabras clave
- Red meat, Medicine, Very low-density lipoprotein, Logistic regression, Cholesterol, Dyslipidemia, Physiology, Internal medicine, Disease, Food science, Lipoprotein, Biology
- MeSH
- humans, myocardial ischemia, triglycerides, diet, risk factors, meat, biological specimen banks, female, male, biomarkers, red meat, united kingdom
3 autores
- Bohan Fan🇭🇰University of Hong Kong
- Xin Yue Huang🇭🇰University of Hong Kong
- Jie V. Zhao🇭🇰 · autor de correspondenciaUniversity of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Growing evidence suggests that red meat consumption is a risk factor for cardiovascular health, with potential sex disparity. The metabolic mechanisms have not been fully understood. Using the UK Biobank, first we examined the associations of unprocessed red meat and processed meat with ischemic heart disease (IHD) mortality overall and by sex using logistic regression. Then, we examined the overall and sex-specific associations of red meat consumption with metabolites using multivariable regression, as well as the associations of selected metabolites with IHD mortality using logistic regression. We further selected metabolic biomarkers that are linked to both red meat consumption and IHD, with concordant directions. Unprocessed red meat and processed meat consumption was associated with higher IHD mortality overall and in men. Thirteen metabolites were associated with both unprocessed red meat and IHD mortality overall and showed a consistent direction, including triglycerides in different lipoproteins, phospholipids in very small very-low-density lipoprotein (VLDL), docosahexaenoic acid, tyrosine, creatinine, glucose, and glycoprotein acetyls. Ten metabolites related to triglycerides and VLDL were positively associated with both unprocessed red meat consumption and IHD mortality in men, but not in women. Processed meat consumption showed similar results with unprocessed red meat. Triglycerides in lipoproteins, fatty acids, and some nonlipid metabolites may play a role linking meat consumption to IHD. Triglycerides and VLDL-related lipid metabolism may contribute to the sex-specific associations. Sex differences should be considered in dietary recommendations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.