Physiological and biochemical responses to caffeine and microplastics in Mytilus galloprovincialis
Impellitteri F, Yunko K, Martyniuk V, Matskiv T, Lechachenko S, Khoma V, Mudra A, Piccione G, Stoliar O, Faggio C
The Science of the total environment · 46 citas
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Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Università degli Studi di Messina
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-05-23 · Sci Total Environ · vol. 890 · pág. 164075
- Editorial
- Elsevier BV
- Citado
- 70 citas · más que el 95% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 135 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Microplastics and Plastic Pollution · Environmental Toxicology and Ecotoxicology · Marine Biology and Environmental Chemistry
- Palabras clave
- Mytilus, Microplastics, Oxidative stress, Viability assay, Catalase, Metallothionein, Superoxide dismutase, Glutathione, Lipid peroxidation, Chemistry, Biochemistry, Saliva, Biology, Environmental chemistry, Cell, Ecology, Enzyme
- MeSH
- animals, humans, caffeine, plastics, glutathione, glutathione disulfide, water pollutants, chemical, oxidative stress, mytilus, caspase 3, biomarkers, microplastics
10 autores
- Federica Impellitteri🇮🇹University of Messina
- Kateryna Yunko🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University
- Viktoria Martyniuk🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University
- Tetiana Matskiv🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University; I.Horbachevsky Ternopil National Medical University
- Sofia A. Lechachenko🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University
- Vira Khoma🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University
- Alla Mudra🇺🇦I.Horbachevsky Ternopil National Medical University
- Giuseppe Piccione🇮🇹University of Messina
- Oksana B. Stoliar🇺🇦Ternopil Volodymyr Hnatiuk National Pedagogical University
- Caterina Faggio🇮🇹 · autor de correspondenciaUniversity of Messina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine (Caff) is one of the most widely used substances in the human diet and a well-recognized drug. Its input into surface waters is remarkable, but biological effects on aquatic organisms are unclear, particularly in combination with pollutants of suspected modulatory activity, like microplastics (MP). The aim of this study was to reveal the impact on the marine mussel Mytilus galloprovincialis (Lamark, 1819) of Caff (20.0 μg L-1) in the environmentally relevant combination (Mix) with MP 1 mg L-1 (size 35-50 μm) after the exposure for 14 days. Untreated and exposed to Caff and MP separately groups were also examined. Cell viability and cell volume regulation in hemocytes and digestive cells, as well as the indexes of oxidative stress, glutathione (GSH/GSSG) and metallothioneins levels, and caspase-3 activity in digestive gland were assessed. MP and Mix reduced Mn-superoxide dismutase, catalase, and glutathione S-transferase activities and level of lipid peroxidation, but increased the digestive gland cell viability, GSH/GSSG ratio (by 1.4-1.5-fold), metallothioneins level and their Zn content, while Caff did not affect oxidative stress indexes and metallothionein-related Zn chelation. Protein carbonyls were not targeted in all exposures. The distinguishing feature of the Caff group was the decline (2-fold) in caspase-3 activity and low cell viability. The multi-stress effect of Mix was shown by the worsening of the volume regulation of digestive cells and confirmed by discriminant analysis of biochemical indexes. The special capabilities of M. galloprovincialis as a sentinel organism make it an excellent bio-indicator reflecting the multi-stress effects in sub-chronic exposures to potentially harmful substances. The identification of the modulation of individual effects in combined exposure increases the need to base monitoring programs on studies of multi-stress effects in sub-chronic exposures.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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